Hashim Al-Hashimi

Adjunct Professor in the Department of Biochemistry

Appointments and Affiliations

Transcription Factors May Inadvertently Lock in DNA Mistakes (Oct 21, 2020)
Al-Hashimi Receives Prestigious National Academy of Sciences Award in Molecular Biology (Jan 22, 2020 | School of Medicine)
Foundation Funds an 'Expedition' to Map Novel Structures in the Human Genome (Jul 18, 2018 | School of Medicine)
Molecular Movies of RNA Guide Drug Discovery (May 4, 2018)
A Mutational Timer is Built Into the Chemistry of DNA (Jan 31, 2018)
A weird twist in DNA might explain why it’s such a great blueprint for life (Aug 3, 2016 | The Washington Post)
DNA's Dynamic Nature Well-Suited for Blueprint of Life (Jul 29, 2016)
Biochem Grad Student Finalist for International Prize (Jun 7, 2016)
Drug made from bananas can kill viruses including hepatitis C and flu (Oct 23, 2015 | The Daily Mail)
Duke Announces 2015 Distinguished Professors (May 1, 2015)
‘Quantum jitter’ mechanism behind the random mutations that drive evolution and cancer (Mar 13, 2015 | Science a Gogo)
'Quantum Jitters' Could Form Basis of Evolution, Cancer (Mar 10, 2015)
Hashim Al-Hashimi named director for Center for RNA Biology (Sep 5, 2014)

Szekely, O; Rangadurai, AK; Gu, S; Manghrani, A; Guseva, S; Al-Hashimi, HM, NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: implications for the fidelity of transcription and CRISPR/Cas9 gene editing., Nucleic Acids Res, vol 52 no. 5 (2024), pp. 2672-2685 [10.1093/nar/gkae027] [abs].
Geng, A; Ganser, L; Roy, R; Shi, H; Pratihar, S; Case, DA; Al-Hashimi, HM, An RNA excited conformational state at atomic resolution., Nat Commun, vol 14 no. 1 (2023) [10.1038/s41467-023-43673-6] [abs].
Roy, R; Geng, A; Shi, H; Merriman, DK; Dethoff, EA; Salmon, L; Al-Hashimi, HM, Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble., J Am Chem Soc, vol 145 no. 42 (2023), pp. 22964-22978 [10.1021/jacs.3c04614] [abs].
Gu, S; Szymanski, ES; Rangadurai, AK; Shi, H; Liu, B; Manghrani, A; Al-Hashimi, HM, Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs., Nat Chem Biol, vol 19 no. 7 (2023), pp. 900-910 [10.1038/s41589-023-01306-5] [abs].
Al-Hashimi, HM, Turing, von Neumann, and the computational architecture of biological machines., Proc Natl Acad Sci U S A, vol 120 no. 25 (2023) [10.1073/pnas.2220022120] [abs].