Mary E Klotman

Mary E Klotman

R.J. Reynolds Distinguished Professor of Medicine

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

Appointments and Affiliations

  • R.J. Reynolds Distinguished Professor of Medicine
  • Professor of Medicine
  • Executive Vice President of Health Affairs
  • Dean, School of Medicine
  • Professor of Pathology
  • Professor in Molecular Genetics and Microbiology
  • Member of the Duke Human Vaccine Institute

Contact Information

  • Office Location: Davison Building Room 125, Box 2927, Durham, NC 27710
  • Office Phone: +1 919 684 2455
  • Email Address:
  • Websites:


  • Duke University, 1985
  • Duke University, 1983
  • M.D. Duke University, 1980

Awards, Honors, and Distinctions

  • Elected Member. American Academy of Arts & Sciences. 2021
  • Member. Institute of Medicine of The National Academies. 2014
  • Membership. National Academy of Medicine. 2014

Courses Taught

  • PATHOL 793: Research Independent Study

In the News

Representative Publications

  • Michelini, Z; Negri, D; Biava, M; Baroncelli, S; Spada, M; Leone, P; Bona, R; Blasi, M; Nègre, D; Klotman, ME; Cara, A, Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice., Viral Immunol, vol 27 no. 10 (2014), pp. 512-520 [10.1089/vim.2014.0062] [abs].
  • Blasi, M; Balakumaran, B; Chen, P; Negri, DRM; Cara, A; Chen, BK; Klotman, ME, Renal epithelial cells produce and spread HIV-1 via T-cell contact., AIDS, vol 28 no. 16 (2014), pp. 2345-2353 [10.1097/QAD.0000000000000398] [abs].
  • Micsenyi, AM; Zony, C; Alvarez, RA; Durham, ND; Chen, BK; Klotman, ME, Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells., J Infect Dis, vol 208 no. 11 (2013), pp. 1756-1767 [10.1093/infdis/jit362] [abs].
  • Hutter, R; Huang, L; Speidl, WS; Giannarelli, C; Trubin, P; Bauriedel, G; Klotman, ME; Fuster, V; Badimon, JJ; Klotman, PE, Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma., Circulation, vol 128 no. 22 (2013), pp. 2351-2363 [10.1161/CIRCULATIONAHA.113.004634] [abs].
  • Blasi, M; Negri, D; Santra, S; Parks, R; Shen, X; Tomaras, G; Permar, S; Montefiori, D; LaBranche, C; Ferrari, G; Alam, M; Liao, H; Moody, AM; Haynes, BF; Klotman, ME; Cara, A, A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys, AIDS RESEARCH AND HUMAN RETROVIRUSES, vol 29 no. 11 (2013), pp. A161-A161 [abs].
  • Todd, RF; Salata, RA; Klotman, ME; Weisfeldt, ML; Katz, JT; Xian, SX; Hearn, DP; Lipner, RS, Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007., Acad Med, vol 88 no. 11 (2013), pp. 1747-1753 [10.1097/ACM.0b013e3182a7f627] [abs].
  • Blasi, M; Rossi, A; Michelini, Z; Leone, P; Perretta, G; Cimarelli, A; Klotman, ME; Negri, D; Cara, A, Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines, Retrovirology, vol 9 no. S2 (2012) [10.1186/1742-4690-9-s2-p293] [abs].
  • Negri, DRM; Rossi, A; Blasi, M; Michelini, Z; Leone, P; Chiantore, MV; Baroncelli, S; Perretta, G; Cimarelli, A; Klotman, ME; Cara, A, Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines., Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-69] [abs].
  • Papeta, N; Kiryluk, K; Patel, A; Sterken, R; Kacak, N; Snyder, HJ; Imus, PH; Mhatre, AN; Lawani, AK; Julian, BA; Wyatt, RJ; Novak, J; Wyatt, CM; Ross, MJ; Winston, JA; Klotman, ME; Cohen, DJ; Appel, GB; D'Agati, VD; Klotman, PE; Gharavi, AG, APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy., J Am Soc Nephrol, vol 22 no. 11 (2011), pp. 1991-1996 [10.1681/ASN.2011040434] [abs].
  • Jao, J; Palmer, D; Leus, I; Tih, P; Baweja, M; Klotman, M; Sperling, R; Wyatt, C, Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon., Nephrol Dial Transplant, vol 26 no. 9 (2011), pp. 3051-3053 [10.1093/ndt/gfr310] [abs].
  • Chen, P; Chen, BK; Mosoian, A; Hays, T; Ross, MJ; Klotman, PE; Klotman, ME, Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells., J Am Soc Nephrol, vol 22 no. 3 (2011), pp. 496-507 [10.1681/ASN.2010040379] [abs].
  • Ding, J; Rapista, A; Teleshova, N; Lu, W; Klotman, ME; Chang, TL, Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides., J Innate Immun, vol 3 no. 2 (2011), pp. 208-212 [10.1159/000322355] [abs].