Mary E Klotman
R.J. Reynolds Distinguished Professor of MedicineDr. Klotman became Dean of the Duke School of Medicine in June 2017.
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.
Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.
Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)
Appointments and Affiliations
- R.J. Reynolds Distinguished Professor of Medicine
- Professor of Medicine
- Dean, School of Medicine
- Professor in Molecular Genetics and Microbiology
- Professor of Pathology
- Member of the Duke Human Vaccine Institute
- Office Location: Davison Building Room 125, Box 2927, Durham, NC 27710
- Office Phone: (919) 684-2455
- Email Address: firstname.lastname@example.org
- Duke University, 1985
- Duke University, 1983
- M.D. Duke University, 1980
Awards, Honors, and Distinctions
- Elected Member. American Academy of Arts & Sciences. 2021
- Member. Institute of Medicine of The National Academies. 2014
- Membership. National Academy of Medicine. 2014
- PATHOL 793: Research Independent Study
In the News
- Responding to the Omicron Variant (Jan 14, 2022)
- Fall Semester Safety: A Conversation with Sally Kornbluth and Mary Klotman (Aug 21, 2021)
- A Video of Thanks Highlighting the School of Medicine's Response to COVID-19 (Apr 4, 2021)
- Women of Duke Health (Mar 15, 2021 | Medical Center Archives)
- How Close Are We to a COVID-19 Vaccine? (Sep 14, 2020)
- A Quick Mobilization on COVID-19 Research at Duke (Mar 18, 2020)
- A Love Story of Two Medical Deans (Feb 13, 2020 | Texas Medical Center)
- Building Bridges Within Duke Health (Nov 22, 2019 | School of Medicine)
- What's Duke Doing to Better Understand and Treat Brain Diseases? (May 18, 2018 | Viewpoints podcast)
- Why is it Important to Explore the Early-life Origins of Health and Disease? (Mar 5, 2018 | Viewpoints podcast)
- Dean Mary Klotman on Translating Duke Health (Jan 19, 2018 | Viewpoint podcast)
- Mary Klotman: What Did it Take to Change HIV From a Fatal Diagnosis to an Often-manageable, Disease? (Nov 2, 2017 | School of Medicine Viewpoint Podcast)
- Mary Klotman: What is Data Science and Why Is It Important? (Oct 10, 2017 | School of Medicine Viewpoint)
- Dr. Mary Klotman: Why Diversity Is Necessary in Academic Medicine (Aug 29, 2017)
- From Undergraduate to Dean: Dr. Mary Klotman Describes What She Has Learned at Duke (Jul 11, 2017)
- Duke Hosts Precision Medicine World Conference (May 25, 2017 | School of Medicine)
- Klotman Joins Roundtable Discussion with Rep. David Price to Discuss NIH Budget (Apr 24, 2017 | Duke School of Medicine)
- Dr. Mary Klotman Named Dean of Duke School of Medicine (Jan 30, 2017)
- Duke HIV researchers receive large federal grants (Apr 6, 2015 | The News & Observer)
- Duke Research Teams Win Large Federal Grants for HIV Vaccine Studies (Apr 5, 2015)
- Klotman, chair of Medicine, Named to Institute of Medicine (Oct 21, 2014)
- Michelini, Z; Negri, D; Biava, M; Baroncelli, S; Spada, M; Leone, P; Bona, R; Blasi, M; Nègre, D; Klotman, ME; Cara, A, Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice., Viral Immunol, vol 27 no. 10 (2014), pp. 512-520 [10.1089/vim.2014.0062] [abs].
- Blasi, M; Balakumaran, B; Chen, P; Negri, DRM; Cara, A; Chen, BK; Klotman, ME, Renal epithelial cells produce and spread HIV-1 via T-cell contact., Aids, vol 28 no. 16 (2014), pp. 2345-2353 [10.1097/QAD.0000000000000398] [abs].
- Micsenyi, AM; Zony, C; Alvarez, RA; Durham, ND; Chen, BK; Klotman, ME, Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells., J Infect Dis, vol 208 no. 11 (2013), pp. 1756-1767 [10.1093/infdis/jit362] [abs].
- Hutter, R; Huang, L; Speidl, WS; Giannarelli, C; Trubin, P; Bauriedel, G; Klotman, ME; Fuster, V; Badimon, JJ; Klotman, PE, Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma., Circulation, vol 128 no. 22 (2013), pp. 2351-2363 [10.1161/CIRCULATIONAHA.113.004634] [abs].
- Blasi, M; Negri, D; Santra, S; Parks, R; Shen, X; Tomaras, G; Permar, S; Montefiori, D; LaBranche, C; Ferrari, G; Alam, M; Liao, H; Moody, AM; Haynes, BF; Klotman, ME; Cara, A, A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys, Aids Research and Human Retroviruses, vol 29 no. 11 (2013), pp. A161-A161 [abs].
- Todd, RF; Salata, RA; Klotman, ME; Weisfeldt, ML; Katz, JT; Xian, SX; Hearn, DP; Lipner, RS, Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007., Acad Med, vol 88 no. 11 (2013), pp. 1747-1753 [10.1097/ACM.0b013e3182a7f627] [abs].
- Blasi, M; Rossi, A; Michelini, Z; Leone, P; Perretta, G; Cimarelli, A; Klotman, ME; Negri, D; Cara, A, Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines, Retrovirology, vol 9 no. S2 (2012) [10.1186/1742-4690-9-s2-p293] [abs].
- Negri, DRM; Rossi, A; Blasi, M; Michelini, Z; Leone, P; Chiantore, MV; Baroncelli, S; Perretta, G; Cimarelli, A; Klotman, ME; Cara, A, Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines., Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-69] [abs].
- Papeta, N; Kiryluk, K; Patel, A; Sterken, R; Kacak, N; Snyder, HJ; Imus, PH; Mhatre, AN; Lawani, AK; Julian, BA; Wyatt, RJ; Novak, J; Wyatt, CM; Ross, MJ; Winston, JA; Klotman, ME; Cohen, DJ; Appel, GB; D'Agati, VD; Klotman, PE; Gharavi, AG, APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy., J Am Soc Nephrol, vol 22 no. 11 (2011), pp. 1991-1996 [10.1681/ASN.2011040434] [abs].
- Jao, J; Palmer, D; Leus, I; Tih, P; Baweja, M; Klotman, M; Sperling, R; Wyatt, C, Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon., Nephrol Dial Transplant, vol 26 no. 9 (2011), pp. 3051-3053 [10.1093/ndt/gfr310] [abs].
- Chen, P; Chen, BK; Mosoian, A; Hays, T; Ross, MJ; Klotman, PE; Klotman, ME, Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells., J Am Soc Nephrol, vol 22 no. 3 (2011), pp. 496-507 [10.1681/ASN.2010040379] [abs].
- Ding, J; Rapista, A; Teleshova, N; Lu, W; Klotman, ME; Chang, TL, Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides., J Innate Immun, vol 3 no. 2 (2011), pp. 208-212 [10.1159/000322355] [abs].