Louis Edwin DeFrate

Louis Edwin DeFrate

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor in Orthopaedic Surgery
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 789: Internship in Biomedical Engineering
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Zhao, Q; Holt, A; Spritzer, CE; DeFrate, LE; McNulty, AL; Wang, N, High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging., Quant Imaging Med Surg, vol 14 no. 4 (2024), pp. 2738-2746 [10.21037/qims-23-1355] [abs].
  • Heckelman, LN; Kratzer, AL; Spritzer, CE; Soher, BJ; Lewis, BD; DeFrate, LE, Influence of running on femoroacetabular joint bone-to-bone distances., J Orthop Res, vol 42 no. 4 (2024), pp. 837-842 [10.1002/jor.25735] [abs].
  • Coppock, JA; Zimmer, NE; Spritzer, CE; Goode, AP; DeFrate, LE, Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI., Osteoarthr Cartil Open, vol 5 no. 3 (2023) [10.1016/j.ocarto.2023.100378] [abs].
  • Coppock, JA; McNulty, AL; Porter Starr, KN; Holt, AG; Borack, MS; Kosinski, AS; Collins, AT; Bales, CW; DeFrate, LE, The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis., Osteoarthr Cartil Open, vol 5 no. 3 (2023) [10.1016/j.ocarto.2023.100376] [abs].
  • Kim-Wang, SY; Spritzer, CE; Owusu-Akyaw, K; Coppock, JA; Goode, AP; Englander, ZA; Wittstein, JR; DeFrate, LE, The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI: Response., Am J Sports Med, vol 51 no. 8 (2023), pp. NP22-NP24 [10.1177/03635465231172184] [abs].