Louis Edwin DeFrate

Louis Edwin DeFrate

Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study

In the News

Representative Publications

  • Cutcliffe, HC; Kottamasu, PK; McNulty, AL; Goode, AP; Spritzer, CE; DeFrate, LE, Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping., J Biomech, vol 129 (2021) [10.1016/j.jbiomech.2021.110771] [abs].
  • Heckelman, LN; Wesorick, BR; DeFrate, LE; Lee, RH, Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans., J Biomech, vol 128 (2021) [10.1016/j.jbiomech.2021.110707] [abs].
  • Kim-Wang, SY; Holt, AG; McGowan, AM; Danyluk, ST; Goode, AP; Lau, BC; Toth, AP; Wittstein, JR; DeFrate, LE; Yi, JS; McNulty, AL, Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries., Arthritis Research & Therapy, vol 23 no. 1 (2021) [10.1186/s13075-021-02661-1] [abs].
  • Andress, B; Kim, JH; Cutcliffe, HC; Amendola, A; Goode, AP; Varghese, S; DeFrate, LE; McNulty, AL, Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., J Orthop Res, vol 39 no. 10 (2021), pp. 2177-2186 [10.1002/jor.24954] [abs].
  • Coppock, JA; Danyluk, ST; Englander, ZA; Spritzer, CE; Goode, AP; DeFrate, LE, Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test., Journal of Biomechanics, vol 121 (2021) [10.1016/j.jbiomech.2021.110392] [abs].