Louis Edwin DeFrate

Louis Edwin DeFrate

Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 791: Graduate Independent Study

In the News

Representative Publications

  • Kim-Wang, SY; Bradley, PX; Cutcliffe, HC; Collins, AT; Crook, BS; Paranjape, CS; Spritzer, CE; DeFrate, LE, Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery., J Biomech, vol 149 (2023) [10.1016/j.jbiomech.2023.111473] [abs].
  • Bradley, PX; Thomas, KN; Kratzer, AL; Robinson, AC; Wittstein, JR; DeFrate, LE; McNulty, AL, The Interplay of Biomechanical and Biological Changes Following Meniscus Injury., Current Rheumatology Reports, vol 25 no. 2 (2023), pp. 35-46 [10.1007/s11926-022-01093-3] [abs].
  • Foody, JN; Bradley, PX; Spritzer, CE; Wittstein, JR; DeFrate, LE; Englander, ZA, Elevated In Vivo ACL Strain Is Associated With a Straight Knee in Both the Sagittal and the Coronal Planes., Am J Sports Med, vol 51 no. 2 (2023), pp. 422-428 [10.1177/03635465221141876] [abs].
  • Coppock, JA; Zimmer, NE; Englander, ZA; Danyluk, ST; Kosinski, AS; Spritzer, CE; Goode, AP; DeFrate, LE, In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time., Osteoarthritis Cartilage, vol 31 no. 1 (2023), pp. 126-133 [10.1016/j.joca.2022.09.008] [abs].
  • Kim-Wang, SY; Spritzer, CE; Owusu-Akyaw, K; Coppock, JA; Goode, AP; Englander, ZA; Wittstein, JR; DeFrate, LE, The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI., Am J Sports Med, vol 51 no. 1 (2023), pp. 58-65 [10.1177/03635465221131551] [abs].