Loretta Georgina Que

Loretta Georgina Que

Professor of Medicine

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Appointments and Affiliations

  • Professor of Medicine
  • Chief, Division of Pulmonary

Contact Information

  • Office Location: 279 MSRB1, Durham, NC 27710
  • Office Phone: +1 919 681 8551
  • Email Address: loretta.que@duke.edu


  • Duke University, 1996
  • Yale University, 1992
  • M.D. The University of Chicago, 1989

Research Interests

     Obese asthma
     Airway inflammation and airway remodeling
Oxidative stress
Xenon MRI
COVID 19 related lung disease

In the News

Representative Publications

  • Wahidi, MM; Silvestri, GA; Coakley, RD; Ferguson, JS; Shepherd, RW; Moses, L; Conforti, J; Que, LG; Anstrom, KJ; McGuire, F; Colt, H; Downie, GH, A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows., Chest, vol 137 no. 5 (2010), pp. 1040-1049 [10.1378/chest.09-1234] [abs].
  • Que, LG; Yang, Z; Stamler, JS; Lugogo, NL; Kraft, M, S-nitrosoglutathione reductase: an important regulator in human asthma., Am J Respir Crit Care Med, vol 180 no. 3 (2009), pp. 226-231 [10.1164/rccm.200901-0158OC] [abs].
  • Chudgar, SM; Cox, CE; Que, LG; Andolsek, K; Knudsen, NW; Clay, AS, Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?, Crit Care Med, vol 37 no. 1 (2009), pp. 49-60 [10.1097/CCM.0b013e31819265c8] [abs].
  • Lugogo, NL; Ginsburg, GS; Que, LG, Genetic profiling and tailored therapy in asthma: are we there yet?, Curr Opin Mol Ther, vol 9 no. 6 (2007), pp. 528-537 [abs].
  • Whalen, EJ; Foster, MW; Matsumoto, A; Ozawa, K; Violin, JD; Que, LG; Nelson, CD; Benhar, M; Keys, JR; Rockman, HA; Koch, WJ; Daaka, Y; Lefkowitz, RJ; Stamler, JS, Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2., Cell, vol 129 no. 3 (2007), pp. 511-522 [10.1016/j.cell.2007.02.046] [abs].
  • Clay, AS; Que, L; Petrusa, ER; Sebastian, M; Govert, J, Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching., Crit Care Med, vol 35 no. 3 (2007), pp. 738-754 [10.1097/01.CCM.0000257329.22025.18] [abs].
  • Que, LG; Liu, L; Yan, Y; Whitehead, GS; Gavett, SH; Schwartz, DA; Stamler, JS, Protection from experimental asthma by an endogenous bronchodilator., Science, vol 308 no. 5728 (2005), pp. 1618-1621 [10.1126/science.1108228] [abs].
  • Liu, L; Yan, Y; Zeng, M; Zhang, J; Hanes, MA; Ahearn, G; McMahon, TJ; Dickfeld, T; Marshall, HE; Que, LG; Stamler, JS, Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock., Cell, vol 116 no. 4 (2004), pp. 617-628 [10.1016/s0092-8674(04)00131-x] [abs].
  • Yu, Q; Que, LG; Rockey, DC, Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver., Am J Physiol Gastrointest Liver Physiol, vol 282 no. 3 (2002), pp. G565-G572 [10.1152/ajpgi.00512.2000] [abs].
  • Que, LG; George, SE; Gotoh, T; Mori, M; Huang, Y-CT, Effects of arginase isoforms on NO Production by nNOS., Nitric Oxide, vol 6 no. 1 (2002), pp. 1-8 [10.1006/niox.2001.0355] [abs].
  • Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS, A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans., Nature, vol 410 no. 6827 (2001), pp. 490-494 [10.1038/35068596] [abs].
  • Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS; Steverding, D, Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase., Redox Rep, vol 6 no. 4 (2001), pp. 209-210 [10.1179/135100001101536337] [abs].
  • Que, LG; Tony Huang, YC, Pharmacologic adjuncts during mechanical ventilation., Semin Respir Crit Care Med, vol 21 no. 3 (2000), pp. 223-232 [10.1055/s-2000-9848] [abs].
  • Lau, CL; Bentley, RC; Gockerman, JP; Que, LG; D'Amico, TA, Malignant melanoma presenting as a mediastinal mass., Ann Thorac Surg, vol 67 no. 3 (1999), pp. 851-852 [10.1016/s0003-4975(99)00075-2] [abs].
  • Que, LG; Kantrow, SP; Jenkinson, CP; Piantadosi, CA; Huang, YC, Induction of arginase isoforms in the lung during hyperoxia., Am J Physiol, vol 275 no. 1 (1998), pp. L96-102 [10.1152/ajplung.1998.275.1.L96] [abs].
  • Que, LG; Kang, BH; Huang, YC; Piantadosi, CA; Chang, LY, Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis., Shock, vol 9 no. 4 (1998), pp. 304-309 [10.1097/00024382-199804000-00011] [abs].
  • Carraway, MS; Welty-Wolf, KE; Kantrow, SP; Huang, YC; Simonson, SG; Que, LG; Kishimoto, TK; Piantadosi, CA, Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons., Am J Respir Crit Care Med, vol 157 no. 3 Pt 1 (1998), pp. 938-949 [10.1164/ajrccm.157.3.9707129] [abs].