Loretta Georgina Que

Professor of Medicine
Key words: nitrosative defense, lung injury, nitric oxide
Appointments and Affiliations
- Professor of Medicine
- Chief, Division of Pulmonary
Contact Information
- Office Location: 279 Msrb1, Durham, NC 27710
- Office Phone: (919) 681-8551
- Email Address: loretta.que@duke.edu
Education
- Duke University, 1996
- Yale University, 1992
- M.D. The University of Chicago, 1989
Research Interests
AsthmaObese asthma
Airway inflammation and airway remodeling
Oxidative stress
COPD
Xenon MRI
COVID 19 related lung disease
In the News
- The Mystery of Long COVID: Brain Fog, Fatigue, Even Sexual Dysfunction (Mar 9, 2022)
- We Are What We Breathe (Apr 23, 2021 | School of Medicine Magnify)
Representative Publications
- Wahidi, MM; Silvestri, GA; Coakley, RD; Ferguson, JS; Shepherd, RW; Moses, L; Conforti, J; Que, LG; Anstrom, KJ; McGuire, F; Colt, H; Downie, GH, A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows., Chest, vol 137 no. 5 (2010), pp. 1040-1049 [10.1378/chest.09-1234] [abs].
- Que, LG; Yang, Z; Stamler, JS; Lugogo, NL; Kraft, M, S-nitrosoglutathione reductase: an important regulator in human asthma., American Journal of Respiratory and Critical Care Medicine, vol 180 no. 3 (2009), pp. 226-231 [10.1164/rccm.200901-0158OC] [abs].
- Chudgar, SM; Cox, CE; Que, LG; Andolsek, K; Knudsen, NW; Clay, AS, Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?, Crit Care Med, vol 37 no. 1 (2009), pp. 49-60 [10.1097/CCM.0b013e31819265c8] [abs].
- Lugogo, NL; Ginsburg, GS; Que, LG, Genetic profiling and tailored therapy in asthma: are we there yet?, Current Opinion in Molecular Therapeutics, vol 9 no. 6 (2007), pp. 528-537 [abs].
- Whalen, EJ; Foster, MW; Matsumoto, A; Ozawa, K; Violin, JD; Que, LG; Nelson, CD; Benhar, M; Keys, JR; Rockman, HA; Koch, WJ; Daaka, Y; Lefkowitz, RJ; Stamler, JS, Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2., Cell, vol 129 no. 3 (2007), pp. 511-522 [10.1016/j.cell.2007.02.046] [abs].
- Clay, AS; Que, L; Petrusa, ER; Sebastian, M; Govert, J, Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching., Critical Care Medicine, vol 35 no. 3 (2007), pp. 738-754 [10.1097/01.CCM.0000257329.22025.18] [abs].
- Que, LG; Liu, L; Yan, Y; Whitehead, GS; Gavett, SH; Schwartz, DA; Stamler, JS, Protection from experimental asthma by an endogenous bronchodilator., Science, vol 308 no. 5728 (2005), pp. 1618-1621 [10.1126/science.1108228] [abs].
- Liu, L; Yan, Y; Zeng, M; Zhang, J; Hanes, MA; Ahearn, G; McMahon, TJ; Dickfeld, T; Marshall, HE; Que, LG; Stamler, JS, Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock., Cell, vol 116 no. 4 (2004), pp. 617-628 [10.1016/s0092-8674(04)00131-x] [abs].
- Yu, Q; Que, LG; Rockey, DC, Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver., American Journal of Physiology Gastrointestinal and Liver Physiology, vol 282 no. 3 (2002), pp. G565-G572 [10.1152/ajpgi.00512.2000] [abs].
- Que, LG; George, SE; Gotoh, T; Mori, M; Huang, Y-CT, Effects of arginase isoforms on NO Production by nNOS., Nitric Oxide, vol 6 no. 1 (2002), pp. 1-8 [10.1006/niox.2001.0355] [abs].
- Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS, A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans., Nature, vol 410 no. 6827 (2001), pp. 490-494 [10.1038/35068596] [abs].
- Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS; Steverding, D, Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase., Redox Report : Communications in Free Radical Research, vol 6 no. 4 (2001), pp. 209-210 [10.1179/135100001101536337] [abs].
- Que, LG; Tony Huang, YC, Pharmacologic adjuncts during mechanical ventilation., Seminars in Respiratory and Critical Care Medicine, vol 21 no. 3 (2000), pp. 223-232 [10.1055/s-2000-9848] [abs].
- Lau, CL; Bentley, RC; Gockerman, JP; Que, LG; D'Amico, TA, Malignant melanoma presenting as a mediastinal mass., The Annals of Thoracic Surgery, vol 67 no. 3 (1999), pp. 851-852 [10.1016/s0003-4975(99)00075-2] [abs].
- Que, LG; Kantrow, SP; Jenkinson, CP; Piantadosi, CA; Huang, YC, Induction of arginase isoforms in the lung during hyperoxia., The American Journal of Physiology, vol 275 no. 1 (1998), pp. L96-102 [10.1152/ajplung.1998.275.1.L96] [abs].
- Que, LG; Kang, BH; Huang, YC; Piantadosi, CA; Chang, LY, Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis., Shock (Augusta, Ga.), vol 9 no. 4 (1998), pp. 304-309 [10.1097/00024382-199804000-00011] [abs].
- Carraway, MS; Welty-Wolf, KE; Kantrow, SP; Huang, YC; Simonson, SG; Que, LG; Kishimoto, TK; Piantadosi, CA, Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons., American Journal of Respiratory and Critical Care Medicine, vol 157 no. 3 Pt 1 (1998), pp. 938-949 [10.1164/ajrccm.157.3.9707129] [abs].