Hashim Al-Hashimi

Hashim Al-Hashimi

James B. Duke Distinguished Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Distinguished Professor of Biochemistry
  • Professor of Biochemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu


  • Ph.D. Yale University, 2000

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • BIOCHEM 700: Graduate Training Internship
  • PHARM 493: Research Independent Study

In the News

Representative Publications

  • Shi, H; Kimsey, IJ; Gu, S; Liu, H-F; Pham, U; Schumacher, MA; Al-Hashimi, HM, Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA., Nucleic Acids Res, vol 49 no. 21 (2021), pp. 12540-12555 [10.1093/nar/gkab936] [abs].
  • Liu, B; Shi, H; Al-Hashimi, HM, Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids., Curr Opin Struct Biol, vol 70 (2021), pp. 16-25 [10.1016/j.sbi.2021.02.007] [abs].
  • Liu, B; Shi, H; Rangadurai, A; Nussbaumer, F; Chu, C-C; Erharter, KA; Case, DA; Kreutz, C; Al-Hashimi, HM, A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-25253-8] [abs].
  • Kelly, ML; Chu, C-C; Shi, H; Ganser, LR; Bogerd, HP; Huynh, K; Hou, Y; Cullen, BR; Al-Hashimi, HM, Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays., Rna (New York, N.Y.), vol 27 no. 1 (2021), pp. 12-26 [10.1261/rna.076257.120] [abs].
  • Abou Assi, H; Rangadurai, AK; Shi, H; Liu, B; Clay, MC; Erharter, K; Kreutz, C; Holley, CL; Al-Hashimi, HM, 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states., Nucleic Acids Res, vol 48 no. 21 (2020), pp. 12365-12379 [10.1093/nar/gkaa928] [abs].