Hashim Al-Hashimi

Hashim Al-Hashimi

James B. Duke Distinguished Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Distinguished Professor of Biochemistry
  • Adjunct Professor in the Department of Biochemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu

Education

  • Ph.D. Yale University, 2000

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • BIOCHEM 700: Graduate Training Internship
  • PHARM 493: Research Independent Study

In the News

Representative Publications

  • Rangadurai, A; Shi, H; Xu, Y; Liu, B; Abou Assi, H; Boom, JD; Zhou, H; Kimsey, IJ; Al-Hashimi, HM, Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting., Proc Natl Acad Sci U S A, vol 119 no. 24 (2022) [10.1073/pnas.2112496119] [abs].
  • Lai, LB; Lai, SM; Szymanski, ES; Kapur, M; Choi, EK; Al-Hashimi, HM; Ackerman, SL; Gopalan, V, Structural basis for impaired 5' processing of a mutant tRNA associated with defects in neuronal homeostasis., Proc Natl Acad Sci U S A, vol 119 no. 10 (2022) [10.1073/pnas.2119529119] [abs].
  • Shi, H; Kimsey, IJ; Gu, S; Liu, H-F; Pham, U; Schumacher, MA; Al-Hashimi, HM, Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA., Nucleic Acids Res, vol 49 no. 21 (2021), pp. 12540-12555 [10.1093/nar/gkab936] [abs].
  • Liu, B; Shi, H; Al-Hashimi, HM, Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids., Curr Opin Struct Biol, vol 70 (2021), pp. 16-25 [10.1016/j.sbi.2021.02.007] [abs].
  • Liu, B; Shi, H; Rangadurai, A; Nussbaumer, F; Chu, C-C; Erharter, KA; Case, DA; Kreutz, C; Al-Hashimi, HM, A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-25253-8] [abs].