2019 Kaganov Symposium on Pulmonary Medicine and Engineering

2019 Kaganov Symposium on Pulmonary Medicine and Engineering

Thursday, May 2, 2019
Great Hall, Trent Semans Center
11:30 A.M - 4:30 P.M
Lunch Provided
Registration Required

Speakers:

Ed Morrisey, Ph.D., University of Pennsylvania

Professor of Medicine and Cell and Developmental Biology
Director, Penn Center for Pulmonary Biology (PCPB)
Scientific Director, Penn Institute for Regenerative Medicine

The Morrisey Lab focuses on the molecular pathways that regulate cardiovascular and lung development. Currently, our interests include the role of forkhead and GATA transcription factors in cardiac, smooth muscle and lung epithelial development and the role of Wnt signaling in cardiovascular and lung development. We utilize in vivo loss and gain of function techniques including mouse knock-outs to define how these factors and pathways regulate developmental processes. We are also interested in how these transcription factors and signaling pathways regulate cardiovascular and pulmonary homeostasis and injury repair. Our long term goal is to define the molecular mechanisms underlying cardiovascular and pulmonary development and determine whether these mechanisms are recapitulated in adult disease.
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Daniel Tschumperlin, Ph.D., Mayo Clinic

Consultant, Department of Physiology & Biomedical Engineering
Consultant, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine
Associate Professor of Biomedical Engineering
Professor of Physiology

Tschumperlin's reseach focuses on the respiratory system and how the structure, function and mechanics of the lung are regulated in health and disease.

Lung function is inherently mechanical in nature, and changes to the structure and mechanical properties of the lung are central in a number of respiratory conditions. Moreover, changes in respiratory mechanics can alter cellular function, resulting in feedback loops that drive disease progression. Researching the interplay between mechanics, structure and cellular function within normal and diseased lungs will ultimately lead to better treatments for respiratory diseases such as pulmonary fibrosis, pulmonary hypertension and asthma.
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Agenda

11:30 A.M. – Lunch served

12:15 P.M.Opening remarks
Ravi Bellamkonda, Ph.D.
Dean, Pratt School of Engineering
Duke University

12:30 P.M. - Development and regeneration of the lung alveolar niche.
Edward Morrisey, Ph.D.
Department of Medicine, Perelman School of Medicine
University of Pennsylvania

1:30 P.M.An injectable depot of glucagon-like peptide-1 ameliorates airway remodeling and fibrosis in obese asthmatics.
Loretta Que, M.D.
Division of Pulmonary, Allergy, and Critical Care Medicine
Duke University

1:50 P.M.DAMPing fibrosis through understanding cell contractility
Scott Palmer, M.D.
Division of Pulmonary, Allergy, and Critical Care Medicine
Brent Hoffman, Ph.D.
Department of Biomedical Engineering
David Brass, Ph.D.
Division of Pulmonary, Allergy, and Critical Care Medicine
Duke University

2:10 P.M.Organoid models for lung disease modeling
Purushothama Rao Tata, Ph.D.
Department of Cell Biology
Duke University

2:30 PM Break

2:40 P.M.Introducing 2018–2019 Kaganov Research Initiative grant recipients

2:55 P.M.Introducing Duke Design Health
Eric Richardson, Ph.D.
Department of Biomedical Engineering
Duke University

3:05 P.M.Targeting mechanobiological mediators of fibrosis
Daniel Tschumperlin, Ph.D.
Department of Physiology & Biomedical Engineering
Mayo Clinic College of Medicine and Science

4:05 P.M.Panel discussion: Future Directions
Moderator: George Truskey, Ph.D.
Department of Biomedical Engineering
Duke University

4:20 PM – Conclude