Kaganov Research Initiative in Pulmonary Medicine and Engineering Seminar: Making or Breaking the Lungs: Fibroblasts in Alveolar Development and Fibrosis
Tuesday, March 5, 2019
4:30 pm - 5:30 pm
James S. Hagood, MD
Professor of Pediatrics, Division of Pulmonology, UNC School of Medicine Director, Program for Rare and Interstitial Lung Disease, Children's Research Institute and Marsico Lung Institute Dr. Hagood is a pediatric pulmonologist specializing in rare lung disease. His "Lung Repair Lab" studies the molecular regulation of fibroblast phenotypes in pulmonary fibrotic disease and lung alveolarization. He also studies the roles and regulation of Thy-1, a critical modulator of cellular phenotype, and epigenetic/epigenomic alterations in lung development and disease, as well as targeted therapy for diffuse lung diseases. Additionally, the lab studies the role of extracellular vesicles, such as exosomes, in altering cell phenotypes in the context of lung repair and remodeling. More recently, Dr. Hagood has joined two collaborative efforts to create a comprehensive cellular and molecular map of the developing and mature lung, the LungMAP, funded by the National Heart, Lung and Blood Institute, and the HuBMAP, supported by the NIH Common fund.