Smita Kesavan Nair

Smita K Nair

Professor in Surgery

I have 22 years of experience in the field of cancer vaccines and immunotherapy and I am an accomplished T cell immunologist. Laboratory website:
https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory

Current projects in the Nair Laboratory:
1] Dendritic cell vaccines using tumor-antigen encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)
2] Local immune receptor modulation using mRNA that encodes for antibodies, receptor-ligands, cytokines, chemokines and toll-like receptors (current target list: CTLA4, GITR, PD1, TIM3, LAG3, OX40 and 41BB)
3] Combination therapies for cancer: cytotoxic therapy (radiation, chemo and oncolytic poliovirus therapy) with dendritic cell-based vaccines and immune checkpoint blockade
4] Adoptive T cell therapy using tumor RNA-transfected dendritic cells to expand tumor-specific T cells ex vivo
5] Adoptive T cell therapy using PSMA CAR (chimeric antigen receptor) RNA-transfected T cells
6] Direct injection of tumor antigen encoding RNA (targeting antigens to dendric cells in vivo using nanoparticles and aptamers)

Appointments and Affiliations

  • Professor in Surgery
  • Professor in Pathology
  • Professor in Neurosurgery
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: Room 1077, Msrb-2, 106 Research Drive, Durham, NC 27710
  • Office Phone: (919) 681-2180
  • Websites:

Education

  • Ph.D. University of Tennessee, Knoxville, 1993

Courses Taught

  • BIOLOGY 293: Research Independent Study
  • BIOLOGY 493: Research Independent Study
  • PATHOL 793: Research Independent Study

In the News