Shiva Kumar Das

Shiva Kumar Das

Adjunct Professor in the Department of Radiation Oncology

Intensity Modulated Radiotherapy optimization. Functional Image-guided radiotherapy (PET, SPECT). Modeling of Radiation-induced normal tissue complications (lung, cardiac) using neural nets, MART, self organizing maps, etc. Optimal selection of beam orientations for radiotherapy. Hyperthermia modeling.

Current Funded Grants:
NCI P01 CA042745-19: Hyperthermia and Perfusion Effects in Cancer Therapy Project 2: Real Time Modeling and Control Using Finite Elements and MRI (Program Director).
NCI 1R01 CA115748-01A1: Accurate Prediction of Cardiac and Lung Radiation Injury (Principal Investigator).
Varian Medical Systems: Incorporation of Functional Image-guidance in Radiotherapy Planning (Principal Investigator).

Graduate School Teaching:
MP322: Advanced Photon Beam Radiation Therapy Planning (Fall Semester)

Postdoctoral Research Associates (Past and Current):
Alan Baydush, Ph.D.
Shifeng Chen, Ph.D.
Kung-Shan Cheng, Ph.D.
Sarah McGuire, Ph.D.
Vadim Stakhursky, Ph.D.

Appointments and Affiliations

  • Adjunct Professor in the Department of Radiation Oncology

Contact Information

  • Office Location: 04216 Hosp South, Durham, NC 27710
  • Office Phone: +1 919 681 5424
  • Email Address:


  • Ph.D. Duke University, 1990

Courses Taught

  • MEDPHY 781: Clinical Shadowing for Medical Physicists

Representative Publications

  • Yin, F-F; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, S-M, Physics and imaging for targeting of oligometastases., Semin Radiat Oncol, vol 16 no. 2 (2006), pp. 85-101 [10.1016/j.semradonc.2005.12.004] [abs].
  • Das, SK; Macfall, J; McCauley, R; Craciunescu, O; Dewhirst, MW; Samulski, TV, Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data., Int J Hyperthermia, vol 21 no. 7 (2005), pp. 657-667 [10.1080/02656730500186346] [abs].
  • Das, SK; Baydush, AH; Zhou, S; Miften, M; Yu, X; Craciunescu, O; Oldham, M; Light, K; Wong, T; Blazing, M; Borges-Neto, S; Dewhirst, MW; Marks, LB, Predicting radiotherapy-induced cardiac perfusion defects., Med Phys, vol 32 no. 1 (2005), pp. 19-27 [10.1118/1.1823571] [abs].
  • Zhou, S-M; Das, S; Wang, Z; Marks, LB, Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model., Med Phys, vol 31 no. 9 (2004), pp. 2606-2609 [10.1118/1.1783532] [abs].
  • Baydush, AH; Marks, LB; Das, SK, Penalized likelihood fluence optimization with evolutionary components for intensity modulated radiation therapy treatment planning., Med Phys, vol 31 no. 8 (2004), pp. 2335-2343 [10.1118/1.1773631] [abs].
  • Das, SK; Miften, MM; Zhou, S; Bell, M; Munley, MT; Whiddon, CS; Craciunescu, O; Baydush, AH; Wong, T; Rosenman, JG; Dewhirst, MW; Marks, LB, Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions., Med Phys, vol 31 no. 6 (2004), pp. 1452-1461 [10.1118/1.1750991] [abs].
  • Das, SK; Bell, M; Marks, LB; Rosenman, JG, A preliminary study of the role of modulated electron beams in intensity modulated radiotherapy, using automated beam orientation and modality selection., Int J Radiat Oncol Biol Phys, vol 59 no. 2 (2004), pp. 602-617 [10.1016/j.ijrobp.2004.01.049] [abs].
  • Miften, MM; Das, SK; Su, M; Marks, LB, Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose., Phys Med Biol, vol 49 no. 9 (2004), pp. 1711-1721 [10.1088/0031-9155/49/9/009] [abs].
  • Miften, MM; Das, SK; Su, M; Marks, LB, A dose-volume-based tool for evaluating and ranking IMRT treatment plans., J Appl Clin Med Phys, vol 5 no. 4 (2004), pp. 1-14 [10.1120/jacmp.v5i4.1981] [abs].
  • Das, S; Cullip, T; Tracton, G; Chang, S; Marks, L; Anscher, M; Rosenman, J, Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization., Int J Radiat Oncol Biol Phys, vol 55 no. 1 (2003), pp. 215-224 [10.1016/s0360-3016(02)03817-8] [abs].
  • Miften, MM; Das, SK; Shafman, TD; Marks, LB, Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy., Med Phys, vol 29 no. 12 (2002), pp. 2891-2896 [10.1118/1.1524169] [abs].
  • Craciunescu, OI; Raaymakers, BW; Kotte, AN; Das, SK; Samulski, TV; Lagendijk, JJ, Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements., Med Phys, vol 28 no. 11 (2001), pp. 2289-2296 [10.1118/1.1408619] [abs].
  • Hernando, ML; Marks, LB; Bentel, GC; Zhou, SM; Hollis, D; Das, SK; Fan, M; Munley, MT; Shafman, TD; Anscher, MS; Lind, PA, Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer., Int J Radiat Oncol Biol Phys, vol 51 no. 3 (2001), pp. 650-659 [10.1016/s0360-3016(01)01685-6] [abs].
  • Kang, SK; Chou, RH; Dodge, RK; Clough, RW; Kang, HL; Bowen, MG; Steffey, BA; Das, SK; Zhou, SM; Whitehurst, AW; Buckley, NJ; Kim, JH; Joyner, RE; Sarmina, I; Montana, GS; Ingram, SS; Anscher, MS, Acute urinary toxicity following transperineal prostate brachytherapy using a modified Quimby loading method., Int J Radiat Oncol Biol Phys, vol 50 no. 4 (2001), pp. 937-945 [10.1016/s0360-3016(01)01530-9] [abs].
  • Craciunescu, OI; Das, SK; Poulson, JM; Samulski, TV, Three-dimensional tumor perfusion reconstruction using fractal interpolation functions., IEEE Trans Biomed Eng, vol 48 no. 4 (2001), pp. 462-473 [10.1109/10.915713] [abs].
  • Das, SK; Jones, EA; Samulski, TV, A method of MRI-based thermal modelling for a RF phased array., Int J Hyperthermia, vol 17 no. 6 (2001), pp. 465-482 [10.1080/02656730110068320] [abs].
  • Craciunescu, OI; Das, SK; McCauley, RL; MacFall, JR; Samulski, TV, 3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements., Int J Hyperthermia, vol 17 no. 3 (2001), pp. 221-239 [10.1080/02656730110041149] [abs].
  • Craciunescu, OI; Das, SK; Clegg, ST, Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion., J Biomech Eng, vol 121 no. 5 (1999), pp. 480-486 [10.1115/1.2835076] [abs].
  • Das, SK; Clegg, ST; Samulski, TV, Computational techniques for fast hyperthermia temperature optimization., Med Phys, vol 26 no. 2 (1999), pp. 319-328 [10.1118/1.598519] [abs].
  • Das, SK; Clegg, ST; Samulski, TV, Electromagnetic thermal therapy power optimization for multiple source applicators., Int J Hyperthermia, vol 15 no. 4 (1999), pp. 291-308 [10.1080/026567399285666] [abs].
  • Das, SK; Marks, LB, Selection of coplanar or noncoplanar beams using three-dimensional optimization based on maximum beam separation and minimized nontarget irradiation., Int J Radiat Oncol Biol Phys, vol 38 no. 3 (1997), pp. 643-655 [10.1016/s0360-3016(97)89489-8] [abs].
  • Clegg, ST; Das, SK; Fullar, E; Anderson, S; Blivin, J; Oleson, JR; Samulski, TV, Hyperthermia treatment planning and temperature distribution reconstruction: a case study., Int J Hyperthermia, vol 12 no. 1 (1996), pp. 65-76 [10.3109/02656739609023690] [abs].
  • Das, SK; Clegg, ST; Anscher, MS; Samulski, TV, Simulation of electromagnetically induced hyperthermia: a finite element gridding method., Int J Hyperthermia, vol 11 no. 6 (1995), pp. 797-808 [10.3109/02656739509052336] [abs].
  • Clegg, ST; Das, SK; Zhang, Y; Macfall, J; Fullar, E; Samulski, TV, Verification of a hyperthermia model method using MR thermometry., Int J Hyperthermia, vol 11 no. 3 (1995), pp. 409-424 [10.3109/02656739509022476] [abs].