Nicholas Scott Heaton

Nicholas Scott Heaton

Assistant Professor of Molecular Genetics and Microbiology

Appointments and Affiliations

  • Assistant Professor of Molecular Genetics and Microbiology
  • Member of the Duke Cancer Institute
  • Member of the Duke Cancer Institute
  • Member of the Duke Human Vaccine Institute

Contact Information

  • Email Address:


  • Ph.D. The University of Chicago, 2012

Courses Taught

  • MGM 593: Research Independent Study
  • MGM 701: Foundations of Molecular Genetics and Microbiology

In the News

Representative Publications

  • Katsura, H; Sontake, V; Tata, A; Kobayashi, Y; Edwards, CE; Heaton, BE; Konkimalla, A; Asakura, T; Mikami, Y; Fritch, EJ; Lee, PJ; Heaton, NS; Boucher, RC; Randell, SH; Baric, RS; Tata, PR, Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction., Cell Stem Cell, vol 27 no. 6 (2020), pp. 890-904.e8 [10.1016/j.stem.2020.10.005] [abs].
  • Froggatt, HM; Heaton, BE; Heaton, NS, Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay., J Virol, vol 94 no. 22 (2020) [10.1128/JVI.01265-20] [abs].
  • Dumm, RE; Wellford, SA; Moseman, EA; Heaton, NS, Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses., Cell Reports, vol 32 no. 9 (2020) [10.1016/j.celrep.2020.108103] [abs].
  • Abbott, TR; Dhamdhere, G; Liu, Y; Lin, X; Goudy, L; Zeng, L; Chemparathy, A; Chmura, S; Heaton, NS; Debs, R; Pande, T; Endy, D; La Russa, MF; Lewis, DB; Qi, LS, Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza., Cell, vol 181 no. 4 (2020), pp. 865-876.e12 [10.1016/j.cell.2020.04.020] [abs].
  • Chambers, BS; Heaton, BE; Rausch, K; Dumm, RE; Hamilton, JR; Cherry, S; Heaton, NS, DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection., Nature Microbiology, vol 4 no. 11 (2019), pp. 1964-1977 [10.1038/s41564-019-0509-3] [abs].