Louis Edwin DeFrate

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Appointments and Affiliations

• Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
• Professor in Orthopaedic Surgery
• Professor in the Department of Biomedical Engineering
• Affiliate of the Duke Regeneration Center

Contact Information

• Office Location: Room 379, Medical Sciences Research Building, Box 3093 Med. Ctr., Durham, NC 27710
• Office Phone: (919) 681-9959
• Email Address: lou.defrate@duke.edu
• Websites:
  • Google Scholar
  • Musculoskeletal Bioengineering Laboratory

Education

• Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

• Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

• BME 791: Graduate Independent Study
• BME 792: Continuation of Graduate Independent Study

In the News

• Duke Awards 44 Distinguished Professorships (May 4, 2023 | Duke Today)
• Study Shows Men and Women Tear ACL the Same Way In Non-Contact Injury (Apr 18, 2018 | Duke Health News)
• His and Her Knee Injuries Occur the Same Way (Apr 18, 2018 | US News and World Report)
• How to prevent knee injuries (Dec 1, 2017 | KSAT News)
• Knee arthritis in Americans has doubled since 1940 (Aug 17, 2017 | Science Magazine)
• Athletes: Try this to prevent ACL tears and knee injuries (Aug 10, 2017 | WRAL News)
• Clinical Sciences Day: Collaboration, Mentorship Lead to Science Successes (Oct 22, 2013 | Duke Research Blog)

Representative Publications

• Coppock, JA; McNulty, AL; Porter Starr, KN; Holt, AG; Borack, MS; Kosinski, AS; Collins, AT; Bales, CW; DeFrate, LE, The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis., Osteoarthr Cartil Open, vol 5 no. 3 (2023) [10.1016/j.ocarto.2023.100376] [abs].
• Coppock, JA; Zimmer, NE; Spritzer, CE; Goode, AP; DeFrate, LE, Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI., Osteoarthr Cartil Open, vol 5 no. 3 (2023) [10.1016/j.ocarto.2023.100378] [abs].
• Kim-Wang, SY; Spritzer, CE; Owusu-Akyaw, K; Coppock, JA; Goode, AP; Englander, ZA; Wittstein, JR; DeFrate, LE, The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI: Response., Am J Sports Med, vol 51 no. 8 (2023), pp. NP22-NP24 [10.1177/03635465231172184] [abs].
• Kim-Wang, SY; Bradley, PX; Cutcliffe, HC; Collins, AT; Crook, BS; Paranjape, CS; Spritzer, CE; DeFrate, LE, Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery., J Biomech, vol 149 (2023) [10.1016/j.jbiomech.2023.111473] [abs].
• Bradley, PX; Thomas, KN; Kratzer, AL; Robinson, AC; Wittstein, JR; DeFrate, LE; McNulty, AL, The Interplay of Biomechanical and Biological Changes Following Meniscus Injury., Current Rheumatology Reports, vol 25 no. 2 (2023), pp. 35-46 [10.1007/s11926-022-01093-3] [abs].