Kim Marie Huffman

Kim Marie Huffman

Associate Professor of Medicine

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Appointments and Affiliations

  • Associate Professor of Medicine
  • Affiliate of the Duke Regeneration Center
  • Member of Duke Molecular Physiology Institute

Contact Information

  • Office Location: 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
  • Office Phone: +1 919 668 1644
  • Email Address:


  • Duke University, 2005
  • Duke University, 2002
  • M.D. Medical University of South Carolina, College of Medicine, 2000
  • Ph.D. Medical University of South Carolina, College of Medicine, 1998

Courses Taught

  • BIOLOGY 493: Research Independent Study
  • BIOLOGY 293: Research Independent Study

In the News

Representative Publications

  • Huffman, KM; Pieper, CF; Kraus, VB; Kraus, WE; Fillenbaum, GG; Cohen, HJ, Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults., J Gerontol A Biol Sci Med Sci, vol 66 no. 12 (2011), pp. 1369-1375 [10.1093/gerona/glr121] [abs].
  • Slentz, CA; Bateman, LA; Willis, LH; Shields, AT; Tanner, CJ; Piner, LW; Hawk, VH; Muehlbauer, MJ; Samsa, GP; Nelson, RC; Huffman, KM; Bales, CW; Houmard, JA; Kraus, WE, Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT., Am J Physiol Endocrinol Metab, vol 301 no. 5 (2011), pp. E1033-E1039 [10.1152/ajpendo.00291.2011] [abs].
  • Huffman, KM; Slentz, CA; Kraus, WE, Control arms in exercise training studies: transitioning from an era of intervention efficacy to one of comparative clinical effectiveness research., J Appl Physiol (1985), vol 111 no. 3 (2011), pp. 946-948 [10.1152/japplphysiol.00323.2011] [abs].
  • Lum, H; Sloane, R; Huffman, KM; Kraus, VB; Thompson, DK; Kraus, WE; Bain, JR; Stevens, R; Pieper, CF; Taylor, GA; Newgard, CB; Cohen, HJ; Morey, MC, Plasma acylcarnitines are associated with physical performance in elderly men., J Gerontol A Biol Sci Med Sci, vol 66 no. 5 (2011), pp. 548-553 [10.1093/gerona/glr006] [abs].
  • Denoble, AE; Huffman, KM; Stabler, TV; Kelly, SJ; Hershfield, MS; McDaniel, GE; Coleman, RE; Kraus, VB, Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation., Proc Natl Acad Sci U S A, vol 108 no. 5 (2011), pp. 2088-2093 [10.1073/pnas.1012743108] [abs].
  • Redman, LM; Huffman, KM; Landerman, LR; Pieper, CF; Bain, JR; Muehlbauer, MJ; Stevens, RD; Wenner, BR; Kraus, VB; Newgard, CB; Kraus, WE; Ravussin, E, Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women., J Clin Endocrinol Metab, vol 96 no. 2 (2011), pp. E312-E321 [10.1210/jc.2010-1971] [abs].
  • Huffman, KM; Slentz, CA; Bateman, LA; Thompson, D; Muehlbauer, MJ; Bain, JR; Stevens, RD; Wenner, BR; Kraus, VB; Newgard, CB; Kraus, WE, Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity., Diabetes Care, vol 34 no. 1 (2011), pp. 174-176 [10.2337/dc10-0709] [abs].
  • Hittel, DS; Axelson, M; Sarna, N; Shearer, J; Huffman, KM; Kraus, WE, Myostatin decreases with aerobic exercise and associates with insulin resistance., Med Sci Sports Exerc, vol 42 no. 11 (2010), pp. 2023-2029 [10.1249/MSS.0b013e3181e0b9a8] [abs].
  • Hoenig, H; Huffman, K; Iezzoni, L; Levy, CE; Sonenblum, S; Sprigle, S, Motorized scooters: boon or bane?, Am J Cardiol, vol 106 no. 4 (2010) [10.1016/j.amjcard.2010.05.018] [abs].
  • Huffman, KM; Sloane, R; Peterson, MJ; Bosworth, HB; Ekelund, C; Pearson, M; Howard, T; Pieper, CF; Morey, MC, The impact of self-reported arthritis and diabetes on response to a home-based physical activity counselling intervention., Scand J Rheumatol, vol 39 no. 3 (2010), pp. 233-239 [10.3109/03009740903348973] [abs].
  • Huffman, KM; Hall, KS; Sloane, R; Peterson, MJ; Bosworth, HB; Ekelund, C; Pearson, M; Howard, T; Pieper, CF; Morey, MC, Is diabetes associated with poorer self-efficacy and motivation for physical activity in older adults with arthritis?, Scand J Rheumatol, vol 39 no. 5 (2010), pp. 380-386 [10.3109/03009741003605630] [abs].
  • Slentz, CA; Tanner, CJ; Bateman, LA; Durheim, MT; Huffman, KM; Houmard, JA; Kraus, WE, Effects of exercise training intensity on pancreatic beta-cell function., Diabetes Care, vol 32 no. 10 (2009), pp. 1807-1811 [10.2337/dc09-0032] [abs].
  • Huffman, KM; Shah, SH; Stevens, RD; Bain, JR; Muehlbauer, M; Slentz, CA; Tanner, CJ; Kuchibhatla, M; Houmard, JA; Newgard, CB; Kraus, WE, Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women., Diabetes Care, vol 32 no. 9 (2009), pp. 1678-1683 [10.2337/dc08-2075] [abs].
  • Smith, IJ; Huffman, KM; Durheim, MT; Duscha, BD; Kraus, WE, Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise., Physiol Genomics, vol 36 no. 3 (2009), pp. 149-157 [10.1152/physiolgenomics.90216.2008] [abs].
  • Huffman, KM; Slentz, CA; Johnson, JL; Samsa, GP; Duscha, BD; Tanner, CJ; Annex, BH; Houmard, JA; Kraus, WE, Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults., Metabolism, vol 57 no. 7 (2008), pp. 888-895 [10.1016/j.metabol.2008.01.034] [abs].
  • Huffman, KM; Slentz, CA; Bales, CW; Houmard, JA; Kraus, WE, Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention., Metabolism, vol 57 no. 4 (2008), pp. 577-583 [10.1016/j.metabol.2007.11.023] [abs].
  • Huffman, KM; Orenduff, MC; Samsa, GP; Houmard, JA; Kraus, WE; Bales, CW, Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men., Am Heart J, vol 154 no. 5 (2007), pp. 962-968 [10.1016/j.ahj.2007.07.009] [abs].
  • Huffman, KM; Bowers, JR; Dailiana, Z; Huebner, JL; Urbaniak, JR; Kraus, VB, Synovial fluid metabolites in osteonecrosis., Rheumatology (Oxford), vol 46 no. 3 (2007), pp. 523-528 [10.1093/rheumatology/kel302] [abs].
  • Huffman, KM; Samsa, GP; Slentz, CA; Duscha, BD; Johnson, JL; Bales, CW; Tanner, CJ; Houmard, JA; Kraus, WE, Response of high-sensitivity C-reactive protein to exercise training in an at-risk population., Am Heart J, vol 152 no. 4 (2006), pp. 793-800 [10.1016/j.ahj.2006.04.019] [abs].
  • Huffman, KM; Arrigo, SJ; Schmidt, MG, HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system., J Biomed Sci, vol 6 no. 3 (1999), pp. 194-205 [10.1007/BF02255903] [abs].
  • Huffman, KM; Arrigo, SJ, Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences., Virology, vol 234 no. 2 (1997), pp. 253-260 [10.1006/viro.1997.8655] [abs].
  • Arrigo, SJ; Huffman, K, Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers., J Virol, vol 69 no. 10 (1995), pp. 5988-5994 [10.1128/JVI.69.10.5988-5994.1995] [abs].
  • English, RS; Lorbach, SC; Huffman, KM; Shively, JM, Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid., Plasmid, vol 33 no. 1 (1995), pp. 1-6 [10.1006/plas.1995.1001] [abs].
  • Arrigo, SJ; Haines, JK; Huffman, KM, Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells., DNA Cell Biol, vol 14 no. 1 (1995), pp. 15-23 [10.1089/dna.1995.14.15] [abs].
  • Ella, KM; Meier, GP; Bradshaw, CD; Huffman, KM; Spivey, EC; Meier, KE, A fluorescent assay for agonist-activated phospholipase D in mammalian cell extracts., Anal Biochem, vol 218 no. 1 (1994), pp. 136-142 [10.1006/abio.1994.1152] [abs].