Professor Emeritus of Radiation Oncology
A major interest of mine has been in the design and synthesis of Mn porphyrin(MnP)-based powerful catalytic antioxidants which helped establish structure-activity relationship (SAR). It relates the redox property of metalloporphyrins to their ability to remove superoxide. SAR has facilitated the design of redox-active therapeutics and served as a tool for mechanistic considerations. Importantly SAR parallels the magnitude of the therapeutic potential of SOD mimics and is valid for all classes of redox-active compounds. Two lead Mn porphyrins are already in five Phase II clinical trials (reviewed in Batinic-Haberle et al, Oxid Med Cell Longevity 2021). Recent research suggests immense potential of MnPs in cardiac diseases. MnTE-2-PyP (AEOL10113, BMX-010) prevents and treats cardiac arrhythmia, while MnTnBuOE-2-PyP (BMX-001) fully suppressed the development of aortic sclerosis in mice. The latter result is relevant to the cancer patients undergoing chemotherapy. In addition to breast cancer, in collaboration with Angeles Alvarez Secord, MD, MHSc, we have recently shown the anticancer effects of Mn porphyrin/ascorbate in cellular and mouse models of ovarian cancer.
In parallel with synthetic efforts, I have also been interested in the mechanistic aspects of differential actions of Mn porphyrins in normal vs tumor tissue. In-depth studies of chemistry and biology of the reactions of MnPs with redox-active agents relevant to cancer therapy – ascorbate, chemotherapy and radiation – set ground for understanding the role of thermodynamics and kinetics in the mechanism of action of Mn porphyrins. Mechanistic studies have been revealed in Batinic-Haberle et al, Antioxidant Redox Signal 2018, Batinic-Haberle and Tome, Redox Biology 2019 and Batinic-Haberle et al Oxidative Medicine and Cellular Longevity 2021. My research has resulted in over 230 publications, 18 268 citations and an h-index of 64. For my achievements, I have been awarded the 2021 Discovery Award from the Society for Redox Biology and Medicine, SfRBM.
- Postdoctoral fellowship with Professor Alvin Crumbliss in the field of Bioinorganic Chemistry, Department of Chemistry, Duke University
- Postdoctoral fellowship with Professor Irwin Fridovich in the field of Redox Biology, Department of Biochemistry, Duke University School of Medicine
Appointments and Affiliations
- Professor Emeritus of Radiation Oncology
- Office Location: Duke Hospital South, Orange Zone, Room 5317, 200 Trent Drive, Durham, NC 27710
- Office Phone: (919) 684-2101
- Email Address: email@example.com
- Duke University, 1995
- Ph.D. University of Zagreb (Croatia), 1988
- Li, X; Duan, W; Du, L; Chu, D; Wang, P; Yang, Z; Qu, X; Yang, Z; Batinic-Haberle, I; Spasojevic, I; Warner, DS; Crapo, JD; Treggiari, MM; Sheng, H, Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP5+, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats., Antioxidants (Basel, Switzerland), vol 12 no. 10 (2023) [10.3390/antiox12101861] [abs].
- John, C; Shen, X; Deng, B; Zhao, Z; Zhou, C; Bae-Jump, V; Secord, AA; Batinic-Haberle, I; Spasojevic, I, Ascorbate exhibits anti-tumorigenic effects in pre-clinical models of endometrioid endometrial cancer (043), Gynecologic Oncology, vol 176 (2023), pp. S37-S38 [10.1016/j.ygyno.2023.06.516] [abs].
- Soares, RB; Manguinhas, R; Costa, JG; Saraiva, N; Gil, N; Rosell, R; Camões, SP; Batinic-Haberle, I; Spasojevic, I; Castro, M; Miranda, JP; Guedes de Pinho, P; Fernandes, AS; Oliveira, NG, The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin., Cancers, vol 15 no. 15 (2023) [10.3390/cancers15153814] [abs].
- Sharma, S; Sharma, P; Subedi, U; Bhattarai, S; Miller, C; Manikandan, S; Batinic-Haberle, I; Spasojevic, I; Sun, H; Panchatcharam, M; Miriyala, S, Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress., International Journal of Molecular Sciences, vol 24 no. 7 (2023) [10.3390/ijms24076159] [abs].
- Soares, RB; Manguinhas, R; Costa, JG; Saraiva, N; Gil, N; Rosell, R; Camões, SP; Batinic-Haberle, I; Spasojevic, I; Castro, M; Miranda, JP; Amaro, F; Pinto, J; Fernandes, AS; Guedes de Pinho, P; Oliveira, NG, MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells., Antioxidants (Basel, Switzerland), vol 11 no. 11 (2022) [10.3390/antiox11112198] [abs].