Hashim Al-Hashimi

Hashim Al-Hashimi

James B. Duke Distinguished Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Distinguished Professor of Biochemistry
  • Professor of Biochemistry
  • Professor of Chemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu


  • Ph.D. Yale University, 2000

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

In the News

Representative Publications

  • Kelly, ML; Chu, C-C; Shi, H; Ganser, LR; Bogerd, HP; Huynh, K; Hou, Y; Cullen, BR; Al-Hashimi, HM, Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays., Rna, vol 27 no. 1 (2021), pp. 12-26 [10.1261/rna.076257.120] [abs].
  • Abou Assi, H; Rangadurai, AK; Shi, H; Liu, B; Clay, MC; Erharter, K; Kreutz, C; Holley, CL; Al-Hashimi, HM, 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states., Nucleic Acids Res, vol 48 no. 21 (2020), pp. 12365-12379 [10.1093/nar/gkaa928] [abs].
  • Xu, Y; Manghrani, A; Liu, B; Shi, H; Pham, U; Liu, A; Al-Hashimi, HM, Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage., The Journal of Biological Chemistry, vol 295 no. 47 (2020), pp. 15933-15947 [10.1074/jbc.RA120.014530] [abs].
  • Shi, H; Rangadurai, A; Abou Assi, H; Roy, R; Case, DA; Herschlag, D; Yesselman, JD; Al-Hashimi, HM, Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction., Nature Communications, vol 11 no. 1 (2020) [10.1038/s41467-020-19371-y] [abs].
  • Afek, A; Shi, H; Rangadurai, A; Sahay, H; Senitzki, A; Xhani, S; Fang, M; Salinas, R; Mielko, Z; Pufall, MA; Poon, GMK; Haran, TE; Schumacher, MA; Al-Hashimi, HM; Gordân, R, DNA mismatches reveal conformational penalties in protein-DNA recognition., Nature, vol 587 no. 7833 (2020), pp. 291-296 [10.1038/s41586-020-2843-2] [abs].