Hashim Al-Hashimi

Hashim Al-Hashimi

Adjunct Professor in the Department of Biochemistry

Appointments and Affiliations

  • Adjunct Professor in the Department of Biochemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu

Education

  • Ph.D. Yale University, 2000

Awards, Honors, and Distinctions

  • NAS Award in Molecular Biology. National Academy of Sciences. 2020

Courses Taught

  • PHARM 493: Research Independent Study
  • BIOCHEM 700: Graduate Training Internship
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 393: Research Independent Study

In the News

Representative Publications

  • Gu, S; Al-Hashimi, HM, Direct Measurement of 8OG Syn-Anti Flips in Mutagenic 8OG·A and Long-Range Damage-Dependent Hoogsteen Breathing Dynamics Using 1H CEST NMR., J Phys Chem B, vol 128 no. 17 (2024), pp. 4087-4096 [10.1021/acs.jpcb.4c00316] [abs].
  • Szekely, O; Rangadurai, AK; Gu, S; Manghrani, A; Guseva, S; Al-Hashimi, HM, NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: implications for the fidelity of transcription and CRISPR/Cas9 gene editing., Nucleic Acids Res, vol 52 no. 5 (2024), pp. 2672-2685 [10.1093/nar/gkae027] [abs].
  • Geng, A; Ganser, L; Roy, R; Shi, H; Pratihar, S; Case, DA; Al-Hashimi, HM, An RNA excited conformational state at atomic resolution., Nat Commun, vol 14 no. 1 (2023) [10.1038/s41467-023-43673-6] [abs].
  • Roy, R; Geng, A; Shi, H; Merriman, DK; Dethoff, EA; Salmon, L; Al-Hashimi, HM, Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble., J Am Chem Soc, vol 145 no. 42 (2023), pp. 22964-22978 [10.1021/jacs.3c04614] [abs].
  • Gu, S; Szymanski, ES; Rangadurai, AK; Shi, H; Liu, B; Manghrani, A; Al-Hashimi, HM, Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs., Nat Chem Biol, vol 19 no. 7 (2023), pp. 900-910 [10.1038/s41589-023-01306-5] [abs].