Hashim Al-Hashimi

James B. Duke Distinguished Professor of Biochemistry

Appointments and Affiliations

• James B. Duke Distinguished Professor of Biochemistry
• Professor of Biochemistry
• Professor of Chemistry

Contact Information

• Email Address: hashim.al.hashimi@duke.edu

Education

• Ph.D. Yale University, 2000

Courses Taught

• BIOCHEM 393: Research Independent Study
• BIOCHEM 593: Research Independent Study
• BIOCHEM 695: Understanding NMR Spectroscopy
• PHARM 493: Research Independent Study
• PHARM 494: Research Independent Study

In the News

• Transcription Factors May Inadvertently Lock in DNA Mistakes (Oct 21, 2020)
• Al-Hashimi Receives Prestigious National Academy of Sciences Award in Molecular Biology (Jan 22, 2020 | School of Medicine)
• Foundation Funds an 'Expedition' to Map Novel Structures in the Human Genome (Jul 18, 2018 | School of Medicine)
• Molecular Movies of RNA Guide Drug Discovery (May 4, 2018)
• A Mutational Timer is Built Into the Chemistry of DNA (Jan 31, 2018)
• A weird twist in DNA might explain why it’s such a great blueprint for life (Aug 3, 2016 | The Washington Post)
• DNA's Dynamic Nature Well-Suited for Blueprint of Life (Jul 29, 2016)
• Biochem Grad Student Finalist for International Prize (Jun 7, 2016)
• Drug made from bananas can kill viruses including hepatitis C and flu (Oct 23, 2015 | The Daily Mail)
• Duke Announces 2015 Distinguished Professors (May 1, 2015)
• ‘Quantum jitter’ mechanism behind the random mutations that drive evolution and cancer (Mar 13, 2015 | Science a Gogo)
• 'Quantum Jitters' Could Form Basis of Evolution, Cancer (Mar 11, 2015)
• Hashim Al-Hashimi named director for Center for RNA Biology (Sep 5, 2014)

Representative Publications

• Kelly, ML; Chu, C-C; Shi, H; Ganser, LR; Bogerd, HP; Huynh, K; Hou, Y; Cullen, BR; Al-Hashimi, HM, Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays., Rna, vol 27 no. 1 (2021), pp. 12-26 [10.1261/rna.076257.120] [abs].
• Abou Assi, H; Rangadurai, AK; Shi, H; Liu, B; Clay, MC; Erharter, K; Kreutz, C; Holley, CL; Al-Hashimi, HM, 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states., Nucleic Acids Res, vol 48 no. 21 (2020), pp. 12365-12379 [10.1093/nar/gkaa928] [abs].
• Xu, Y; Manghrani, A; Liu, B; Shi, H; Pham, U; Liu, A; Al-Hashimi, HM, Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage., The Journal of Biological Chemistry, vol 295 no. 47 (2020), pp. 15933-15947 [10.1074/jbc.RA120.014530] [abs].
• Shi, H; Rangadurai, A; Abou Assi, H; Roy, R; Case, DA; Herschlag, D; Yesselman, JD; Al-Hashimi, HM, Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction., Nature Communications, vol 11 no. 1 (2020) [10.1038/s41467-020-19371-y] [abs].
• Afek, A; Shi, H; Rangadurai, A; Sahay, H; Senitzki, A; Xhani, S; Fang, M; Salinas, R; Mielko, Z; Pufall, MA; Poon, GMK; Haran, TE; Schumacher, MA; Al-Hashimi, HM; Gordân, R, DNA mismatches reveal conformational penalties in protein-DNA recognition., Nature, vol 587 no. 7833 (2020), pp. 291-296 [10.1038/s41586-020-2843-2] [abs].