Hashim Al-Hashimi

Hashim Al-Hashimi

James B. Duke Distinguished Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Distinguished Professor of Biochemistry
  • Professor of Biochemistry
  • Professor of Chemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu

Education

  • Ph.D. Yale University, 2000

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

In the News

Representative Publications

  • Rangadurai, A; Szymanski, ES; Kimsey, I; Shi, H; Al-Hashimi, HM, Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion., J Biomol Nmr, vol 74 no. 8-9 (2020), pp. 457-471 [10.1007/s10858-020-00337-7] [abs].
  • Rangadurai, A; Shi, H; Al-Hashimi, HM, Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields., Angew Chem Int Ed Engl, vol 59 no. 28 (2020), pp. 11262-11266 [10.1002/anie.202000493] [abs].
  • Li, P; Rangadurai, A; Al-Hashimi, HM; Hammes-Schiffer, S, Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations., J Am Chem Soc, vol 142 no. 25 (2020), pp. 11183-11191 [10.1021/jacs.0c03774] [abs].
  • Kladwang, W; Topkar, VV; Liu, B; Rangan, R; Hodges, TL; Keane, SC; Al-Hashimi, H; Das, R, Anomalous Reverse Transcription through Chemical Modifications in Polyadenosine Stretches., Biochemistry, vol 59 no. 23 (2020), pp. 2154-2170 [10.1021/acs.biochem.0c00020] [abs].
  • Ganser, LR; Lee, J; Rangadurai, A; Merriman, DK; Kelly, ML; Kansal, AD; Sathyamoorthy, B; Al-Hashimi, HM, Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble., Nat Struct Mol Biol, vol 27 no. 6 (2020) [10.1038/s41594-020-0434-4] [abs].