Hal Cecil Charles

Hal Cecil Charles

Adjunct Associate Professor in the Department of Radiology

Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development.  He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.

Appointments and Affiliations

  • Adjunct Associate Professor in the Department of Radiology
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 2424 Erwin Road, Suite 301, Hock Plaza, Durham, NC 27705
  • Office Phone: +1 919 684 7921
  • Email Address: cecil.charles@duke.edu
  • Websites:


  • Ph.D. University of New Orleans, 1981

Research Interests

Functional Lung Imaging using perfluorinated gases mixed with oxygen.

Awards, Honors, and Distinctions

  • Fellow of the Society. International Society of Magnetic Resonance in Medicine. 2009

Representative Publications

  • Le Graverand, M-PH; Buck, RJ; Wyman, BT; Vignon, E; Mazzuca, SA; Brandt, KD; Piperno, M; Charles, HC; Hudelmaier, M; Hunter, DJ; Jackson, C; Kraus, VB; Link, TM; Majumdar, S; Prasad, PV; Schnitzer, TJ; Vaz, A; Wirth, W; Eckstein, F, Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography., Ann Rheum Dis, vol 69 no. 1 (2010), pp. 155-162 [10.1136/ard.2008.099762] [abs].
  • Kraus, VB; Feng, S; Wang, S; White, S; Ainslie, M; Brett, A; Holmes, A; Charles, HC, Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression., Arthritis Rheum, vol 60 no. 12 (2009), pp. 3711-3722 [10.1002/art.25012] [abs].
  • Hellio Le Graverand, M-P; Buck, RJ; Wyman, BT; Vignon, E; Mazzuca, SA; Brandt, KD; Piperno, M; Charles, HC; Hudelmaier, M; Hunter, DJ; Jackson, C; Kraus, VB; Link, TM; Majumdar, S; Prasad, PV; Schnitzer, TJ; Vaz, A; Wirth, W; Eckstein, F, Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis., Osteoarthritis Cartilage, vol 17 no. 9 (2009), pp. 1177-1185 [10.1016/j.joca.2009.03.008] [abs].
  • Wyatt, C; Soher, B; Maccarini, P; Charles, HC; Stauffer, P; Macfall, J, Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours., Int J Hyperthermia, vol 25 no. 6 (2009), pp. 422-433 [10.1080/02656730903133762] [abs].
  • Eckstein, F; Buck, RJ; Burstein, D; Charles, HC; Crim, J; Hudelmaier, M; Hunter, DJ; Hutchins, G; Jackson, C; Kraus, VB; Lane, NE; Link, TM; Majumdar, LS; Mazzuca, S; Prasad, PV; Schnitzer, TJ; Taljanovic, MS; Vaz, A; Wyman, B; Le Graverand, M-PH; A9001140 Study Group, , Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial., Ann Rheum Dis, vol 67 no. 12 (2008), pp. 1683-1688 [10.1136/ard.2007.076919] [abs].
  • Mazzuca, SA; Hellio Le Graverand, M-P; Vignon, E; Hunter, DJ; Jackson, CG; Kraus, VB; Link, TM; Schnitzer, TJ; Vaz, A; Charles, HC, Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees., Osteoarthritis Cartilage, vol 16 no. 12 (2008), pp. 1555-1559 [10.1016/j.joca.2008.04.010] [abs].
  • Le Graverand, M-PH; Vignon, EP; Brandt, KD; Mazzuca, SA; Piperno, M; Buck, R; Charles, HC; Hunter, DJ; Jackson, CG; Kraus, VB; Link, TM; Schnitzer, TJ; Vaz, A; Wyman, B, Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees., Ann Rheum Dis, vol 67 no. 11 (2008), pp. 1562-1566 [10.1136/ard.2007.077834] [abs].
  • Charles, HC; Kraus, VB; Ainslie, M; Hellio Le Graverand-Gastineau, M-P, Optimization of the fixed-flexion knee radiograph., Osteoarthritis Cartilage, vol 15 no. 11 (2007), pp. 1221-1224 [10.1016/j.joca.2007.05.012] [abs].
  • Tupler, LA; Krishnan, KRR; Greenberg, DL; Marcovina, SM; Payne, ME; MacFall, JR; Charles, HC; Doraiswamy, PM, Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve., Neurobiol Aging, vol 28 no. 11 (2007), pp. 1644-1656 [10.1016/j.neurobiolaging.2006.07.001] [abs].
  • Eckstein, F; Buck, RJ; Wyman, BT; Kotyk, JJ; Le Graverand, M-PH; Remmers, AE; Evelhoch, JL; Hudelmaier, M; Charles, HC, Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA)., Magn Reson Med, vol 58 no. 2 (2007), pp. 402-406 [10.1002/mrm.21290] [abs].
  • Feldman, HH; Ferris, S; Winblad, B; Sfikas, N; Mancione, L; He, Y; Tekin, S; Burns, A; Cummings, J; del Ser, T; Inzitari, D; Orgogozo, J-M; Sauer, H; Scheltens, P; Scarpini, E; Herrmann, N; Farlow, M; Potkin, S; Charles, HC; Fox, NC; Lane, R, Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study., Lancet Neurol, vol 6 no. 6 (2007), pp. 501-512 [10.1016/S1474-4422(07)70109-6] [abs].
  • Eckstein, F; Charles, HC; Buck, RJ; Kraus, VB; Remmers, AE; Hudelmaier, M; Wirth, W; Evelhoch, JL, Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T., Arthritis Rheum, vol 52 no. 10 (2005), pp. 3132-3136 [10.1002/art.21348] [abs].
  • Dewhirst, MW; Poulson, JM; Yu, D; Sanders, L; Lora-Michiels, M; Vujaskovic, Z; Jones, EL; Samulski, TV; Powers, BE; Brizel, DM; Prosnitz, LR; Charles, HC, Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy., Int J Radiat Oncol Biol Phys, vol 61 no. 2 (2005), pp. 480-491 [10.1016/j.ijrobp.2004.06.211] [abs].
  • Farlow, MR; He, Y; Tekin, S; Xu, J; Lane, R; Charles, HC, Impact of APOE in mild cognitive impairment., Neurology, vol 63 no. 10 (2004), pp. 1898-1901 [10.1212/01.wnl.0000144279.21502.b7] [abs].
  • Arias-Mendoza, F; Zakian, K; Schwartz, A; Howe, FA; Koutcher, JA; Leach, MO; Griffiths, JR; Heerschap, A; Glickson, JD; Nelson, SJ; Evelhoch, JL; Charles, HC; Brown, TR; Cooperative Group on MRS Applications in Cancer, , Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies., NMR Biomed, vol 17 no. 6 (2004), pp. 382-391 [10.1002/nbm.915] [abs].
  • Krishnan, KRR; Charles, HC; Doraiswamy, PM; Mintzer, J; Weisler, R; Yu, X; Perdomo, C; Ieni, JR; Rogers, S, Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease., Am J Psychiatry, vol 160 no. 11 (2003), pp. 2003-2011 [10.1176/appi.ajp.160.11.2003] [abs].
  • Vythilingam, M; Charles, HC; Tupler, LA; Blitchington, T; Kelly, L; Krishnan, KRR, Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study., Biol Psychiatry, vol 54 no. 7 (2003), pp. 744-750 [10.1016/s0006-3223(02)01908-x] [abs].
  • Kim, DM; Xanthakos, SA; Tupler, LA; Barboriak, DP; Charles, HC; MacFall, JR; Krishnan, KRR, MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex., Psychiatry Res, vol 114 no. 3 (2002), pp. 149-161 [10.1016/s0925-4927(02)00024-0] [abs].
  • Chen, JG; Edwards, CL; Vidyarthi, S; Pitchumoni, S; Tabrizi, S; Barboriak, D; Charles, HC; Doraiswamy, PM, Learning and recall in subjects at genetic risk for Alzheimer's disease., J Neuropsychiatry Clin Neurosci, vol 14 no. 1 (2002), pp. 58-63 [10.1176/jnp.14.1.58] [abs].
  • Gilmore, JH; Gerig, G; Specter, B; Charles, HC; Wilber, JS; Hertzberg, BS; Kliewer, MA, Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging., Ultrasound Med Biol, vol 27 no. 8 (2001), pp. 1143-1146 [10.1016/s0301-5629(01)00400-8] [abs].
  • Gilmore, JH; van Tol, JJ; Lewis Streicher, H; Williamson, K; Cohen, SB; Greenwood, RS; Charles, HC; Kliewer, MA; Whitt, JK; Silva, SG; Hertzberg, BS; Chescheir, NC, Outcome in children with fetal mild ventriculomegaly: a case series., Schizophr Res, vol 48 no. 2-3 (2001), pp. 219-226 [10.1016/s0920-9964(00)00140-7] [abs].
  • Barboriak, DP; Doraiswamy, PM; Krishnan, KR; Vidyarthi, S; Sylvester, J; Charles, HC, Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype., Neurology, vol 54 no. 11 (2000), pp. 2150-2153 [10.1212/wnl.54.11.2150] [abs].
  • Prescott, DM; Charles, HC; Poulson, JM; Page, RL; Thrall, DE; Vujaskovic, Z; Dewhirst, MW, The relationship between intracellular and extracellular pH in spontaneous canine tumors., Clin Cancer Res, vol 6 no. 6 (2000), pp. 2501-2505 [abs].
  • Chen, JG; Charles, HC; Barboriak, DP; Doraiswamy, PM, Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate., Acta Neurol Scand Suppl, vol 176 (2000), pp. 20-26 [10.1034/j.1600-0404.2000.00303.x] [abs].
  • Vujaskovic, Z; Poulson, JM; Gaskin, AA; Thrall, DE; Page, RL; Charles, HC; MacFall, JR; Brizel, DM; Meyer, RE; Prescott, DM; Samulski, TV; Dewhirst, MW, Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment., Int J Radiat Oncol Biol Phys, vol 46 no. 1 (2000), pp. 179-185 [10.1016/s0360-3016(99)00362-4] [abs].