George A. Truskey
R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
My research interests focus upon the effect of physical forces on the function of vascular cells and skeletal muscle, cell adhesion, and the design of engineered tissues. Current research projects examine the effect of endothelial cell senescence upon permeability to macromolecules and the response to fluid shear stress, the development of microphysiological blood vessels and muscles for evaluation of drug toxicity and the design of engineered endothelialized blood vessels and skeletal muscle bundles.Appointments and Affiliations
- R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
- Professor of Biomedical Engineering
- Senior Associate Dean in the Pratt School of Engineering
- Faculty Network Member of The Energy Initiative
- Affiliate of the Duke Initiative for Science & Society
- Affiliate of the Regeneration Next Initiative
Contact Information
- Office Location: 1395 Fciemas, 101 Science Drive, Durham, NC 27708-0281
- Office Phone: (919) 660-5147
- Email Address: george.truskey@duke.edu
- Websites:
Education
- Ph.D. Massachusetts Institute of Technology, 1985
- B.S.E. University of Pennsylvania, 1979
Research Interests
Cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.Awards, Honors, and Distinctions
- Fellow. American Association for the Advancement of Science (AAAS). 2015
- AAAS Fellow. American Association for the Advancement of Science. 2014
- BMES Distinguished Service Award. Biomedical Engineering Society. 2012
- NIH CSR College of Reviewers. NIH. 2010
- Capers and Marion McDonald Award for Excellence in Mentoring and Advising. Duke University. 2007
- Fellow. Biomedical Engineering Society. 2006
- Fellow. American Institute for Medical and Biological Engineering. 1999
- Fellow. Council on Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association. 1999
- Excellence in Teaching Award. Tau Beta Pi, North Carolina Gamma Chapter. 1998
- Outstanding Scientific Paper in the Journal of Parenteral Science and Technology. Parenteral Drug Association. 1987
Courses Taught
- BME 394: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 566: Transport Phenomena in Cells and Organs (GE, MC)
- BME 590: Special Topics in Biomedical Engineering
- BME 791: Graduate Independent Study
- BME 792: Continuation of Graduate Independent Study
In the News
- An Important Step Forward in Understanding Progeria, a Rare Accelerated-Aging Disease (Feb 6, 2020 | Pratt School of Engineering)
- Big Ideas on a Small Chip Surface (Nov 1, 2019 | Pratt School of Engineering)
- Tissue Chips Take Aim at Atherosclerosis and Rheumatoid Arthritis (Sep 13, 2017 | Pratt School of Engineering)
- Artificial Blood Vessels Mimic Rare Accelerated Aging Disease (Aug 14, 2017 | Pratt School of Engineering)
- Researchers have discovered a fast way to make artificial arteries for testing drugs (Feb 26, 2016 | Gizmodo)
- Rapidly Building Arteries that Produce Biochemical Signals (Feb 18, 2016 | Pratt School of Engineering)
- Grant to Support Science, Engineering Professorships for Women (Jan 14, 2016)
- Five Faculty Named Fellows of American Association for the Advancement of Science (Nov 24, 2014)
- $3 Million NIH Grant to Further 3-D Tissue Chip Research at Duke (Sep 24, 2014 | Pratt School of Engineering)
Representative Publications
- Abutaleb, NO; Truskey, GA, Differentiation and characterization of human iPSC-derived vascular endothelial cells under physiological shear stress., Star Protocols, vol 2 no. 2 (2021) [10.1016/j.xpro.2021.100394] [abs].
- Lee, JH; Chen, Z; He, S; Zhou, J; Tsai, A; Truskey, G; Leong, KW, Emulating Early Atherosclerosis in a Vascular Microphysiological System Using Branched Tissue-Engineered Blood Vessels., Advanced Biology, vol 5 no. 4 (2021) [10.1002/adbi.202000428] [abs].
- Kondash, ME; Ananthakumar, A; Khodabukus, A; Bursac, N; Truskey, GA, Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle., Tissue Engineering and Regenerative Medicine, vol 17 no. 6 (2020), pp. 801-813 [10.1007/s13770-020-00242-y] [abs].
- Zhang, X; Bishawi, M; Zhang, G; Prasad, V; Salmon, E; Breithaupt, JJ; Zhang, Q; Truskey, GA, Modeling early stage atherosclerosis in a primary human vascular microphysiological system., Nature Communications, vol 11 no. 1 (2020) [10.1038/s41467-020-19197-8] [abs].
- Salmon, EE; Breithaupt, JJ; Truskey, GA, Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation., Cells, vol 9 no. 5 (2020) [10.3390/cells9051292] [abs].