W Daniel Stamer

W Daniel Stamer

Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology

My laboratory studies the disease of glaucoma, the second leading cause of blindness in the United States, affecting nearly 3 million people (70 million Worldwide). The primary risk factor for developing glaucoma is ocular hypertension (high intraocular pressure, IOP). IOP is a function of the regulated movement of aqueous humor into and out of the eye.  Elevated IOP in glaucoma is a result of disease in the primary efflux route, the conventional outflow pathway, affecting proper homeostatic control of aqueous humor drainage.

Lowering IOP in glaucoma patients, whether or not they have ocular hypertension, is important because large clinical trials involving tens of thousands of patients repeatedly demonstrate that significant, sustained IOP reduction slows or halts vision loss. Unfortunately, current first-line medical treatments do not target the diseased conventional pathway and do not lower IOP sufficiently in most people with glaucoma. Therefore, finding new, more effective ways to medically control IOP by targeting the conventional pathway is a central goal the Stamer Laboratory.

Using molecular, cellular, organ and mouse model systems, my laboratory seeks to identify and validate novel drug targets in the human conventional outflow pathway to facilitate the development of the next generation of treatments for ocular hypertension and glaucoma.

Appointments and Affiliations

  • Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology
  • Professor of Ophthalmology
  • Co Vice-Chair of Basic Science Research

Contact Information

  • Office Location: DUMC 3802, Durham, NC 27710
  • Office Phone: +1 919 684 3745
  • Email Address: william.stamer@duke.edu

Education

  • Duke University, School of Medicine, 1998
  • University of Arizona, College of Medicine, 1997
  • University of Arizona, College of Medicine, 1996
  • Ph.D. University of Arizona, 1996
  • B.S. University of Arizona, 1990

Courses Taught

  • BIOLOGY 493: Research Independent Study
  • BIOLOGY 293: Research Independent Study

Representative Publications

  • Safa, BN; Fraticelli Guzmán, NS; Li, G; Stamer, WD; Feola, AJ; Ethier, CR, A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway., J Biomech Eng, vol 146 no. 8 (2024) [10.1115/1.4065164] [abs].
  • Li, G; van Batenburg-Sherwood, J; Safa, BN; Fraticelli Guzmán, NS; Wilson, A; Bahrani Fard, MR; Choy, K; de Ieso, ML; Cui, JS; Feola, AJ; Weisz, T; Kuhn, M; Bowes Rickman, C; Farsiu, S; Ethier, CR; Stamer, WD, Aging and intraocular pressure homeostasis in mice., Aging Cell (2024) [10.1111/acel.14160] [abs].
  • Stamer, WD; Crosson, CE; Potter, DE; Kompella, UB, The JOPT Story: 40 Years of Growth and Focus., J Ocul Pharmacol Ther, vol 40 no. 3 (2024), pp. 155-156 [10.1089/jop.2024.29121.editorial] [abs].
  • Safa, BN; Guzmán, NSF; Li, G; Daniel Stamer, W; Feola, AJ; Ross Ethier, C, A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway., bioRxiv (2024) [10.1101/2023.10.17.562754] [abs].
  • Brown, SF-K; Nguyen, H; Mzyk, P; De Ieso, ML; Unser, AM; Brown, I; Ramesh, P; Afzaal, H; Ahmed, F; Torrejon, KY; Nhan, A; Markrush, D; Daly, T; Knecht, E; McConaughy, W; Halmos, S; Liu, ZL; Rennard, R; Peterson, A; Stamer, WD, ANGPTL7 and Its Role in IOP and Glaucoma., Invest Ophthalmol Vis Sci, vol 65 no. 3 (2024) [10.1167/iovs.65.3.22] [abs].