Corinne Mary Linardic

Corinne Mary Linardic

Associate Professor of Pediatrics

Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models and genetically engineered murine models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Using these models, we can study the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic RAS) in rhabdomyosarcoma formation and treatment resistance. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic RAS, and identification of new therapeutic targets for treatment of this childhood cancer.

Appointments and Affiliations

  • Associate Professor of Pediatrics
  • Associate Professor of Pharmacology and Cancer Biology
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: LSRC Bldg Rm B361f, Research Drive, Durham, NC 27710
  • Office Phone: (919) 684-3401
  • Email Address: linar001@mc.duke.edu

Education

  • Duke University, 2001
  • Children's Hospital of Philadelphia, 1999
  • Children's Hospital of Philadelphia, 1998
  • American Board of Pediatrics, 1969
  • M.D. Duke University, 1995
  • Ph.D. Duke University, 1993

Awards, Honors, and Distinctions

  • Annual Gordon G. Hammes Faculty Teaching Award. Graduate students in Basic Biomedical Sciences and the Duke University School of Medicine. 2019

Courses Taught

  • PHARM 393: Research Independent Study
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

Representative Publications

  • Crose, LES; Etheridge, KT; Chen, C; Belyea, B; Talbot, LJ; Bentley, RC; Linardic, CM, FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma., Clinical Cancer Research, vol 18 no. 14 (2012), pp. 3780-3790 [10.1158/1078-0432.CCR-10-3063] [abs].
  • Ignatius, MS; Chen, E; Elpek, NM; Fuller, AZ; Tenente, IM; Clagg, R; Liu, S; Blackburn, JS; Linardic, CM; Rosenberg, AE; Nielsen, PG; Mempel, TR; Langenau, D