Christina Eleanor Barkauskas

Christina Eleanor Barkauskas

Assistant Professor of Medicine

I am a physician-scientist and stem cell biologist focused on understanding the fundamental mechanisms involved in lung injury and repair. I am particularly interested in determining the critical components of the alveolar epithelial stem cell niche and the cellular crosstalk signals that dictate cell identity and behavior during steady state maintenance and repair after injury and infection. I believe this work is fundamental to better understanding the biology of the human lung and the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease that is characterized by relentless scar accumulation in the lung with only minimally effective therapy short of lung transplant.

Through my work, I have developed several areas of expertise which include the following: 1) Development and use of mouse models to genetically manipulate and lineage trace specific cell populations; 2) Isolation and characterization of murine lung cell subpopulations by flow cytometry; 3) Development and use of an ex vivo 3-dimensional organoid assay to study the self-renewal and differentiation of murine alveolar epithelial stem cells and their niche components; 4) Isolation and 3-dimensional culture of alveolar epithelial cells from fresh human lung; 5) Development and analysis of models of experimental lung fibrosis.

Appointments and Affiliations

  • Assistant Professor of Medicine
  • Affiliate of the Duke Regeneration Center

Contact Information

  • Office Location: Dept of Medicine, Durham, NC 27710
  • Office Phone: (919) 681-6845
  • Email Address: christina.barkauskas@duke.edu

Education

  • Duke University School of Medicine, 2012
  • Duke University School of Medicine, 2011
  • Duke University School of Medicine, 2009
  • Duke University, 2008
  • Duke University, 2007
  • M.D. Duke University School of Medicine, 2004

Representative Publications

  • Murray, DD; Babiker, AG; Baker, JV; Barkauskas, CE; Brown, SM; Chang, CC; Davey, VJ; Gelijns, AC; Ginde, AA; Grund, B; Higgs, E; Hudson, F; Kan, VL; Lane, HC; Murray, TA; Paredes, R; Parmar, MK; Pett, S; Phillips, AN; Polizzotto, MN; Reilly, C; Sandkovsky, U; Sharma, S; Teitelbaum, M; Thompson, BT; Young, BE; Neaton, JD; Lundgren, JD, Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)., Clin Trials (2021) [10.1177/17407745211049829] [abs].
  • Mummy, DG; Bier, EA; Wang, Z; Korzekwinski, J; Morrison, L; Barkauskas, C; McAdams, HP; Tighe, RM; Driehuys, B; Mammarappallil, JG, Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia., Radiology, vol 301 no. 1 (2021), pp. 211-220 [10.1148/radiol.2021204149] [abs].
  • Murray, DD; Babiker, AG; Baker, JV; Barkauskas, CE; Brown, SM; Chang, CC; Davey, VJ; Gelijns, AC; Ginde, AA; Grund, B; Higgs, E; Hudson, F; Kan, VL; Lane, HC; Murray, TA; Paredes, R; Parmar, MKB; Pett, S; Phillips, AN; Polizzotto, MN; Reilly, C; Sandkovsky, U; Sharma, S; Teitelbaum, M; Thompson, BT; Young, BE; Neaton, JD; Lundgren, JD, Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)., Medrxiv (2021) [10.1101/2020.11.08.20227876] [abs].
  • ACTIV-3/TICO LY-CoV555 Study Group, ; Lundgren, JD; Grund, B; Barkauskas, CE; Holland, TL; Gottlieb, RL; Sandkovsky, U; Brown, SM; Knowlton, KU; Self, WH; Files, DC; Jain, MK; Benfield, T; Bowdish, ME; Leshnower, BG; Baker, JV; Jensen, J-U; Gardner, EM; Ginde, AA; Harris, ES; Johansen, IS; Markowitz, N; Matthay, MA; Østergaard, L; Chang, CC; Davey, VJ; Goodman, A; Higgs, ES; Murray, DD; Murray, TA; Paredes, R; Parmar, MKB; Phillips, AN; Reilly, C; Sharma, S; Dewar, RL; Teitelbaum, M; Wentworth, D; Cao, H; Klekotka, P; Babiker, AG; Gelijns, AC; Kan, VL; Polizzotto, MN; Thompson, BT; Lane, HC; Neaton, JD, A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19., The New England Journal of Medicine, vol 384 no. 10 (2021), pp. 905-914 [10.1056/NEJMoa2033130] [abs].
  • Wagner, JG; Barkauskas, CE; Vose, A; Lewandowski, RP; Harkema, JR; Tighe, RM, Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains., Environ Health Perspect, vol 128 no. 11 (2020) [10.1289/EHP7255] [abs].