Bastiaan Driehuys

Professor of Radiology
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.Appointments and Affiliations
- Professor of Radiology
- Professor of Biomedical Engineering
Contact Information
- Office Location: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
- Office Phone: (919) 684-7786
- Email Address: bastiaan.driehuys@duke.edu
- Websites:
Education
- Ph.D. Princeton University, 1995
Courses Taught
- BME 792: Continuation of Graduate Independent Study
- PHYSICS 493: Research Independent Study
- PHYSICS 495: Thesis Independent Study
Representative Publications
- Kaushik, SS; Freeman, MS; Cleveland, ZI; Davies, J; Stiles, J; Virgincar, RS; Robertson, SH; He, M; Kelly, KT; Foster, WM; McAdams, HP; Driehuys, B, Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging., J Appl Physiol (1985), vol 115 no. 6 (2013), pp. 850-860 [10.1152/japplphysiol.00092.2013] [abs].
- Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW, Small animal imaging with magnetic resonance microscopy, Ilar Journal, vol 53 no. 1 (2012), pp. 35-53 [abs].
- Driehuys, B; Martinez-Jimenez, S; Cleveland, ZI; Metz, GM; Beaver, DM; Nouls, JC; Kaushik, SS; Firszt, R; Willis, C; Kelly, KT; Wolber, J; Kraft, M; McAdams, HP, Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients., Radiology, vol 262 no. 1 (2012), pp. 279-289 [10.1148/radiol.11102172] [abs].
- Cleveland, ZI; Möller, HE; Hedlund, LW; Nouls, JC; Freeman, MS; Qi, Y; Driehuys, B, In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe., Plos One, vol 7 no. 2 (2012) [10.1371/journal.pone.0031306] [abs].
- Thomas, AC; Nouls, JC; Driehuys, B; Voltz, JW; Fubara, B; Foley, J; Bradbury, JA; Zeldin, DC, Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury., Am J Respir Cell Mol Biol, vol 44 no. 5 (2011), pp. 648-654 [10.1165/rcmb.2009-0287OC] [abs].
- Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B, Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magn Reson Med, vol 65 no. 4 (2011), pp. 1154-1165 [10.1002/mrm.22697] [abs].
- Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kaushik, SS; Kraft, M; Wolber, J; Kelly, KT; McAdams, HP; Driehuys, B, Hyperpolarized Xe MR imaging of alveolar gas uptake in humans., Plos One, vol 5 no. 8 (2010) [10.1371/journal.pone.0012192] [abs].
- Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CSSR; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B, Molecular MRI for sensitive and specific detection of lung metastases., Proc Natl Acad Sci U S A, vol 107 no. 8 (2010), pp. 3693-3697 [10.1073/pnas.1000386107] [abs].
- Cleveland, ZI; Möller, HE; Hedlund, LW; Driehuys, B, Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes., Journal of Physical Chemistry B, vol 113 no. 37 (2009), pp. 12489-12499 [10.1021/jp9049582] [abs].
- Driehuys, B; Möller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW, Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe., Radiology, vol 252 no. 2 (2009), pp. 386-393 [10.1148/radiol.2513081550] [abs].
- Thomas, AC; Potts, EN; Chen, BT; Slipetz, DM; Foster, WM; Driehuys, B, A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI., Nmr Biomed, vol 22 no. 5 (2009), pp. 502-515 [10.1002/nbm.1362] [abs].
- Driehuys, B; Pollaro, J; Cofer, GP, In vivo MRI using real-time production of hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol 60 no. 1 (2008), pp. 14-20 [10.1002/mrm.21651] [abs].
- Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW, Small animal imaging with magnetic resonance microscopy., Ilar Journal, vol 49 no. 1 (2008), pp. 35-53 [10.1093/ilar.49.1.35] [abs].
- Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA, 3He MRI in mouse models of asthma., Magnetic Resonance in Medicine, vol 58 no. 5 (2007), pp. 893-900 [10.1002/mrm.21306] [abs].
- Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA, Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI., Proceedings of the National Academy of Sciences of the United States of America, vol 103 no. 48 (2006), pp. 18278-18283 [10.1073/pnas.0608458103] [abs].
- Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K, Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol 50 no. 6 (2003), pp. 1170-1179 [10.1002/mrm.10649] [abs].
- Babcock, E; Nelson, I; Kadlecek, S; Driehuys, B; Anderson, LW; Hersman, FW; Walker, TG, Hybrid spin-exchange optical pumping of 3He., Physical Review Letters, vol 91 no. 12 (2003) [10.1103/PhysRevLett.91.123003] [abs].
- Ruppert, K; Brookeman, JR; Hagspiel, KD; Driehuys, B; Mugler, JP, NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold., Nmr in Biomedicine, vol 13 no. 4 (2000), pp. 220-228 [10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.co;2-f] [abs].
- Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)., Magnetic Resonance in Medicine, vol 42 no. 4 (1999), pp. 729-737 [10.1002/(sici)1522-2594(199910)42:4<729::aid-mrm15>3.0.co;2-2] [abs].
- Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magnetic Resonance in Medicine, vol 42 no. 4 (1999), pp. 721-728 [10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d] [abs].
- Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Suddarth, SA; Johnson, GA, Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases., Magnetic Resonance in Medicine, vol 41 no. 4 (1999), pp. 800-808 [10.1002/(sici)1522-2594(199904)41:4<800::aid-mrm20>3.0.co;2-k] [abs].
- Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA, Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases., Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol 135 no. 1 (1998), pp. 133-143 [10.1006/jmre.1998.1563] [abs].
- Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J, Dynamics of magnetization in hyperpolarized gas MRI of the lung., Magnetic Resonance in Medicine, vol 38 no. 1 (1997), pp. 66-71 [10.1002/mrm.1910380111] [abs].
- Mugler, JP; Driehuys, B; Brookeman, JR; Cates, GD; Berr, SS; Bryant, RG; Daniel, TM; de Lange, EE; Downs, JH; Erickson, CJ; Happer, W; Hinton, DP; Kassel, NF; Maier, T; Phillips, CD; Saam, BT; Sauer, KL; Wagshul, ME, MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results., Magnetic Resonance in Medicine, vol 37 no. 6 (1997), pp. 809-815 [10.1002/mrm.1910370602] [abs].
- Driehuys, B; Cates, GD; Miron, E; Sauer, K; Walter, DK; Happer, W, High-volume production of laser-polarized 129Xe, Applied Physics Letters, vol 69 no. 12 (1996), pp. 1668-1670 [10.1063/1.117022] [abs].
- MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE, Human lung air spaces: potential for MR imaging with hyperpolarized He-3., Radiology, vol 200 no. 2 (1996), pp. 553-558 [10.1148/radiology.200.2.8685356] [abs].
- Black, RD; Middleton, HL; Cates, GD; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Johnson, GA; Shattuck, MD; Swartz, JC, In vivo He-3 MR images of guinea pig lungs., Radiology, vol 199 no. 3 (1996), pp. 867-870 [10.1148/radiology.199.3.8638019] [abs].
- Driehuys, B; Cates, GD; Happer, W, Surface relaxation mechanisms of laser-polarized 129Xe., Phys Rev Lett, vol 74 no. 24 (1995), pp. 4943-4946 [10.1103/PhysRevLett.74.4943] [abs].
- Albert, MS; Cates, GD; Driehuys, B; Happer, W; Saam, B; Springer, CS; Wishnia, A, Biological magnetic resonance imaging using laser-polarized 129Xe., Nature, vol 370 no. 6486 (1994), pp. 199-201 [10.1038/370199a0] [abs].
- Gatzke, M; Cates, GD; Driehuys, B; Fox, D; Happer, W; Saam, B, Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe., Phys Rev Lett, vol 70 no. 5 (1993), pp. 690-693 [10.1103/PhysRevLett.70.690] [abs].