Andrew Paul Landstrom

Andrew Paul Landstrom

Associate Professor of Pediatrics

Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart.  He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome.  He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member.  He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative.  As a scientist, he is trained in genetics and cell biology.  He runs a research lab exploring the genetic and molecular causes of arrhythmias, sudden unexplained death syndromes, and heart muscle disease (cardiomyopathies).  He utilizes patient-derived induced pluripotent stem cells and genetic mouse models to identify the mechanisms of cardiovascular genetic disease with the goal of developing novel therapies.

Appointments and Affiliations

  • Associate Professor of Pediatrics
  • Director of the Duke Pediatric Research Scholars Program for Physician-Scientist Development
  • Associate Professor in Cell Biology

Contact Information

  • Office Location: Duke University Medical Center, Box 2652, Durham, NC 27710
  • Office Phone: (919) 684-3028
  • Email Address:
  • Websites:


  • American Board of Pediatrics, 2099
  • Baylor College of Medicine, 2018
  • American Board of Pediatrics, 2099
  • Baylor College of Medicine, 2017
  • Baylor College of Medicine, 2018
  • Baylor College of Medicine, 2014
  • Baylor College of Medicine, 2013
  • Ph.D. Mayo School of Health Sciences, 2012
  • M.D. Mayo School of Health Sciences, 2012

Awards, Honors, and Distinctions

  • Fellow. Heart Rhythm Society. 2020
  • Fellow. American Heart Association. 2019
  • Fellow. Society for Pediatric Research. 2019
  • Young Investigator Award. American Heart Association, Council on Cardiovascular Disease in the Young. 2018
  • Best Poster Award. Baylor College of Medicine 6th Annual Cardiovascular Research Institute Symposium. 2017
  • Dan G. McNamara Fellow of the Year Award. Baylor College of Medicine, Dept of Pediatrics, Section of Cardiology. 2017
  • Top Abstract Award. Baylor College of Medicine 5th Annual Cardiovascular Research Institute Symposium. 2016
  • Outstanding Fellow in Pediatrics. Baylor College of Medicine, Dept of Pediatrics House Officers. 2015
  • Adam Cohen Professionalism Award. Baylor College of Medicine, Dept of Pediatrics . 2014
  • Distinguished Educator Award. Baylor College of Medicine, Dept of Pediatrics. 2014
  • Jan Goddard-Finegold Award in Developmental Pediatrics. Baylor College of Medicine, Dept of Pediatrics. 2014
  • Gold Humanism in Medicine Honor Society Inductee. Baylor College of Medicine. 2013

Courses Taught

  • BIOLOGY 293: Research Independent Study
  • BIOLOGY 493: Research Independent Study
  • CELLBIO 493: Research Independent Study
  • HGP 301B: Research in HGP
  • UPGEN 716S: Genetics Student Research

In the News

Representative Publications

  • Parker, LE; Kurzlechner, LM; Landstrom, AP, Induced Pluripotent Stem Cell-Based Modeling of Single-Ventricle Congenital Heart Diseases., Current Cardiology Reports (2023) [10.1007/s11886-023-01852-3] [abs].
  • Koch, RL; Soler-Alfonso, C; Kiely, BT; Asai, A; Smith, AL; Bali, DS; Kang, PB; Landstrom, AP; Akman, HO; Burrow, TA; Orthmann-Murphy, JL; Goldman, DS; Pendyal, S; El-Gharbawy, AH; Austin, SL; Case, LE; Schiffmann, R; Hirano, M; Kishnani, PS, Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource., Mol Genet Metab, vol 138 no. 3 (2023) [10.1016/j.ymgme.2023.107525] [abs].
  • Landstrom, AP; Yang, Q; Sun, B; Perelli, RM; Bidzimou, M-T; Zhang, Z; Aguilar-Sanchez, Y; Alsina, KM; Cao, S; Reynolds, JO; Word, TA; van der Sangen, NMR; Wells, Q; Kannankeril, PJ; Ludwig, A; Kim, JJ; Wehrens, XHT, Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity., Circ Arrhythm Electrophysiol, vol 16 no. 2 (2023) [10.1161/CIRCEP.122.010858] [abs].
  • Parker, LE; Kramer, RJ; Kaplan, S; Landstrom, AP, One gene, two modes of inheritance, four diseases: A systematic review of the cardiac manifestation of pathogenic variants in JPH2-encoded junctophilin-2., Trends Cardiovasc Med, vol 33 no. 1 (2023), pp. 1-10 [10.1016/j.tcm.2021.11.006] [abs].
  • Novembre, J; Stein, C; Asgari, S; Gonzaga-Jauregui, C; Landstrom, A; Lemke, A; Li, J; Mighton, C; Taylor, M; Tishkoff, S, Addressing the challenges of polygenic scores in human genetic research., Am J Hum Genet, vol 109 no. 12 (2022), pp. 2095-2100 [10.1016/j.ajhg.2022.10.012] [abs].