Andrew Paul Landstrom

Andrew Paul Landstrom

Assistant Professor of Pediatrics

I am a pediatric cardiologist and cardiovascular geneticist with both clinical and research interests in the genetic and molecular mechanisms of sudden cardiac arrest in children.  As a physician-scientist, I am trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart.  I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome).  In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease.  Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”.   Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.

Appointments and Affiliations

  • Assistant Professor of Pediatrics
  • Assistant Professor in Cell Biology

Contact Information

  • Office Location: Duke University Medical Center, Box 2652, Durham, NC 27710
  • Office Phone: (919) 684-3028
  • Email Address: andrew.landstrom@duke.edu
  • Websites:

Education

  • American Board of Pediatrics, 2099
  • Baylor College of Medicine, 2018
  • American Board of Pediatrics, 2099
  • Baylor College of Medicine, 2017
  • Baylor College of Medicine, 2018
  • Baylor College of Medicine, 2014
  • Baylor College of Medicine, 2013
  • Ph.D. Mayo School of Health Sciences, 2012
  • M.D. Mayo School of Health Sciences, 2012

Awards, Honors, and Distinctions

  • Young Investigator Award. American Heart Association, Council on Cardiovascular Disease in the Young. 2018
  • Best Poster Award. Baylor College of Medicine 6th Annual Cardiovascular Research Institute Symposium. 2017
  • Dan G. McNamara Fellow of the Year Award. Baylor College of Medicine, Dept of Pediatrics, Section of Cardiology. 2017
  • Top Abstract Award. Baylor College of Medicine 5th Annual Cardiovascular Research Institute Symposium. 2016
  • Outstanding Fellow in Pediatrics. Baylor College of Medicine, Dept of Pediatrics House Officers. 2015
  • Adam Cohen Professionalism Award. Baylor College of Medicine, Dept of Pediatrics . 2014
  • Distinguished Educator Award. Baylor College of Medicine, Dept of Pediatrics. 2014
  • Jan Goddard-Finegold Award in Developmental Pediatrics. Baylor College of Medicine, Dept of Pediatrics. 2014
  • Gold Humanism in Medicine Honor Society Inductee. Baylor College of Medicine. 2013

Courses Taught

  • CELLBIO 493: Research Independent Study

In the News

Representative Publications

  • Musunuru, K; Hershberger, RE; Day, SM; Klinedinst, NJ; Landstrom, AP; Parikh, VN; Prakash, S; Semsarian, C; Sturm, AC; American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology,, Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association., Circulation. Genomic and Precision Medicine, vol 13 no. 4 (2020) [10.1161/hcg.0000000000000067] [abs].
  • Landstrom, AP; Shah, SH, Rare Things Being Common: Implications for Common Genetic Variants in Rare Diseases Like Long-QT Syndrome., Circulation, vol 142 no. 4 (2020), pp. 339-341 [10.1161/CIRCULATIONAHA.120.048339] [abs].
  • Tadros, HJ; Life, CS; Garcia, G; Pirozzi, E; Jones, EG; Datta, S; Parvatiyar, MS; Chase, PB; Allen, HD; Kim, JJ; Pinto, JR; Landstrom, AP, Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes., J Mol Cell Cardiol, vol 142 (2020), pp. 118-125 [10.1016/j.yjmcc.2020.04.005] [abs].
  • Levine, AT; Born, HA; Landstrom, AP; Larson, S; Lee, WL; Dao, AT; Wehrens, XH; Lai, Y-C; Anderson, AE, Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus., Scientific Reports, vol 10 no. 1 (2020) [10.1038/s41598-020-60324-8] [abs].
  • Ezekian, JE; Clippinger, SR; Garcia, JM; Yang, Q; Denfield, S; Jeewa, A; Dreyer, WJ; Zou, W; Fan, Y; Allen, HD; Kim, JJ; Greenberg, MJ; Landstrom, AP, Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction., Journal of the American Heart Association, vol 9 no. 5 (2020) [10.1161/JAHA.119.015111] [abs].