William Michael Foster

William Michael Foster

Professor in Medicine

W. Michael Foster, PhD: Dr. Foster is a Research Professor of Medicine, Division of Pulmonary and Critical Care Medicine at Duke University Medical Center. Dr. Foster graduated from New York University with a PhD degree in Physiology and Environmental Science. Dr.Foster's laboratory utilizes animal models and performs translational studies in human subjects to investigate the biologic effects of respiratory irritants (particulate matter and gases) on airway and parenchymal lung tissues. The research focus is upon barrier function of the respiratory epithelial membrane, the primary location at which inhaled air pollutants initially impinge upon lung tissue. Imaging and exposure techniques developed for human study have also been integrated with initiatives that utilize lab models. Areas of interest and expertise include the following: 1) effects of oxidant-type air pollution on lung epithelial membrane physiology, 2) in vivo functional and biochemical tissue response(s) of the lung (human and animal model), and 3) host (genetic) factors as modulators of the pulmonary response to ambient air pollutants, inhalable irritants, and nuisance bio-aerosols.

Appointments and Affiliations

  • Professor in Medicine

Contact Information:

  • Office Location: Rm 275 Med Sci Res Bldg I, Durham, NC 27710
  • Office Phone: (919) 668-0382
  • Email Address: foste028@mc.duke.edu

Education:

  • Ph.D. New York University, 1975

Representative Publications:

    • Auten, RL; Foster, WM, Biochemical effects of ozone on asthma during postnatal development., Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol 1810 no. 11 (2011), pp. 1114-1119 [10.1016/j.bbagen.2011.01.008] [abs].
    • Lindsey, JY; Ganguly, K; Brass, DM; Li, Z; Potts, EN; Degan, S; Chen, H; Brockway, B; Abraham, SN; Berndt, A; Stripp, BR; Foster, WM; Leikauf, GD; Schulz, H; Hollingsworth, JW, c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice., American journal of respiratory and critical care medicine, vol 183 no. 12 (2011), pp. 1644-1652 [10.1164/rccm.201007-1157OC] [abs].
    • Martinu, T; Kinnier, CV; Gowdy, KM; Kelly, FL; Snyder, LD; Jiang, D; Foster, WM; Garantziotis, S; Belperio, JA; Noble, PW; Palmer, SM, Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3., Journal of Heart and Lung Transplantation, vol 30 no. 6 (2011), pp. 717-725 [10.1016/j.healun.2011.01.711] [abs].
    • Jin, C; Shelburne, CP; Li, G; Potts, EN; Riebe, KJ; Sempowski, GD; Foster, WM; Abraham, SN, Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation., Journal of Clinical Investigation, vol 121 no. 3 (2011), pp. 941-955 [10.1172/JCI43584] [abs].
    • Foster, WM; Adler, KB; Crews, AL; Potts, EN; Fischer, BM; Voynow, JA, MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac., American journal of physiology. Lung cellular and molecular physiology, vol 299 no. 3 (2010), pp. L345-L352 [10.1152/ajplung.00067.2010] [abs].
    • Auten, RL; Potts, EN; Mason, SN; Fischer, B; Huang, Y; Foster, WM, Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice., American journal of respiratory and critical care medicine, vol 180 no. 12 (2009), pp. 1218-1226 [10.1164/rccm.200901-0116OC] [abs].
    • Voynow, JA; Fischer, BM; Zheng, S; Potts, EN; Grover, AR; Jaiswal, AK; Ghio, AJ; Foster, WM, NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans., American journal of respiratory cell and molecular biology, vol 41 no. 1 (2009), pp. 107-113 [10.1165/rcmb.2008-0381OC] [abs].