Stephen Lisberger

Image of Stephen Lisberger

George Barth Geller Professor for Research in Neurobiology

We investigate how the brain learns motor skills, and how we use what we see to guide how we move. Our approaches involve studies of eye movements using behavior, neural recordings, and computational analysis. Our work is done on behaving non-human primates. 

Appointments and Affiliations

  • George Barth Geller Professor for Research in Neurobiology
  • Professor of Neurobiology
  • Chair in the Department of Neurobiology
  • Faculty Network Member of the Duke Institute for Brain Sciences

Contact Information:

  • Office Location: Bryan Research Building, 311 Research Drive Room 327D, Durham, NC 27710
  • Office Phone: (919) 681-7088
  • Email Address: lisberger@neuro.duke.edu

Education:

  • Ph.D. University of Washington, 1976

Awards, Honors, and Distinctions:

  • Fellows. American Academy of Arts and Sciences. 2008
  • Investigator/Alumni Investigator. Howard Hughes Medical Institute. 1997
  • Young Investigator Prize. Society for Neuroscience. 1986

Courses Taught:

  • CELLBIO 710: Papers and Grant Writing Workshop
  • COMPSCI 393: Research Independent Study
  • NEUROBIO 710: Papers and Grant Writing Workshop
  • NEUROBIO 720C: Concepts in Neuroscience II - Sensory/Motor Integration
  • NEUROBIO 735: Quantitative Approaches in Neurobiology
  • NEUROBIO 793: Research in Neurobiology
  • NEUROBIO 795: Special Topics in Neuroscience
  • NEUROSCI 493: Research Independent Study 1
  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 495: Research Independent Study 3
  • NEUROSCI 755: Interdisciplinary Program in Cognitive Neuroscience (IPCN) Independent Research Rotation

Representative Publications:

    • Lisberger, SG; Medina, JF, How and why neural and motor variation are related., Current Opinion in Neurobiology, vol 33 (2015), pp. 110-116 [10.1016/j.conb.2015.03.008] [abs].
    • Joshua, M; Lisberger, SG, A tale of two species: Neural integration in zebrafish and monkeys., Neuroscience, vol 296 (2015), pp. 80-91 [10.1016/j.neuroscience.2014.04.048] [abs].
    • Yang, Y; Lisberger, SG, Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration., Nature, vol 510 no. 7506 (2014), pp. 529-532 [10.1038/nature13282] [abs].
    • Yang, Y; Lisberger, SG, Role of plasticity at different sites across the time course of cerebellar motor learning., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34 no. 21 (2014), pp. 7077-7090 [10.1523/JNEUROSCI.0017-14.2014] [abs].
    • Joshua, M; Lisberger, SG, A framework for using signal, noise, and variation to determine whether the brain controls movement synergies or single muscles., Journal of neurophysiology, vol 111 no. 4 (2014), pp. 733-745 [10.1152/jn.00510.2013] [abs].
    • Yang, Y; Lisberger, SG, Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration, Nature, vol 510 no. 7506 (2014), pp. 529-532 [10.1038/nature13282] [abs].
    • Yang, Y; Lisberger, SG, Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning., Elife, vol 2 (2013) [10.7554/eLife.01574] [abs].
    • Yang, Y; Lisberger, SG, Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning, eLife, vol 2013 no. 2 (2013) [10.7554/eLife.01574] [abs].
    • Lee, J; Lisberger, SG, Gamma synchrony predicts neuron-neuron correlations and correlations with motor behavior in extrastriate visual area MT., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 33 no. 50 (2013), pp. 19677-19688 [10.1523/JNEUROSCI.3478-13.2013] [abs].
    • Hohl, SS; Chaisanguanthum, KS; Lisberger, SG, Sensory population decoding for visually guided movements., Neuron, vol 79 no. 1 (2013), pp. 167-179 [10.1016/j.neuron.2013.05.026] [abs].
    • Lee, J; Yang, J; Lisberger, SG, Control of the gain of visual-motor transmission occurs in visual coordinates for smooth pursuit eye movements., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 33 no. 22 (2013), pp. 9420-9430 [10.1523/JNEUROSCI.4846-12.2013] [abs].
    • Joshua, M; Medina, JF; Lisberger, SG, Diversity of neural responses in the brainstem during smooth pursuit eye movements constrains the circuit mechanisms of neural integration., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 33 no. 15 (2013), pp. 6633-6647 [10.1523/JNEUROSCI.3732-12.2013] [abs].
    • Huang, X; Lisberger, SG, Circuit mechanisms revealed by spike-timing correlations in macaque area MT., Journal of neurophysiology, vol 109 no. 3 (2013), pp. 851-866 [10.1152/jn.00775.2012] [abs].
    • Yang, J; Lee, J; Lisberger, SG, The interaction of bayesian priors and sensory data and its neural circuit implementation in visually guided movement., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 32 no. 49 (2012), pp. 17632-17645 [10.1523/JNEUROSCI.1163-12.2012] [abs].
    • O'Leary, JG; Lisberger, SG, Role of the lateral intraparietal area in modulation of the strength of sensory-motor transmission for visually guided movements., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 32 no. 28 (2012), pp. 9745-9754 [10.1523/JNEUROSCI.0269-12.2012] [abs].
    • Joshua, M; Lisberger, SG, Reward action in the initiation of smooth pursuit eye movements., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 32 no. 8 (2012), pp. 2856-2867 [10.1523/JNEUROSCI.4676-11.2012] [abs].
    • Hohl, SS; Lisberger, SG, Representation of perceptually invisible image motion in extrastriate visual area MT of macaque monkeys., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 31 no. 46 (2011), pp. 16561-16569 [10.1523/JNEUROSCI.3166-11.2011] [abs].
    • Li, JX; Medina, JF; Frank, LM; Lisberger, SG, Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 31 no. 36 (2011), pp. 12716-12726 [10.1523/JNEUROSCI.2515-11.2011] [abs].
    • Niu, Y-Q; Lisberger, SG, Sensory versus motor loci for integration of multiple motion signals in smooth pursuit eye movements and human motion perception., Journal of neurophysiology, vol 106 no. 2 (2011), pp. 741-753 [10.1152/jn.01025.2010] [abs].
    • Chaisanguanthum, KS; Lisberger, SG, A neurally efficient implementation of sensory population decoding., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 31 no. 13 (2011), pp. 4868-4877 [10.1523/JNEUROSCI.6776-10.2011] [abs].
    • Li, JX; Lisberger, SG, Learned timing of motor behavior in the smooth eye movement region of the frontal eye fields., Neuron, vol 69 no. 1 (2011), pp. 159-169 [10.1016/j.neuron.2010.11.043] [abs].
    • Yang, Y; Lisberger, SG, Learning on multiple timescales in smooth pursuit eye movements., Journal of neurophysiology, vol 104 no. 5 (2010), pp. 2850-2862 [10.1152/jn.00761.2010] [abs].
    • Lisberger, SG, Visual guidance of smooth-pursuit eye movements: sensation, action, and what happens in between., Neuron, vol 66 no. 4 (2010), pp. 477-491 [10.1016/j.neuron.2010.03.027] [abs].
    • Medina, JF; Lisberger, SG, Encoding and decoding of learned smooth-pursuit eye movements in the floccular complex of the monkey cerebellum., Journal of neurophysiology, vol 102 no. 4 (2009), pp. 2039-2054 [10.1152/jn.00075.2009] [abs].
    • Osborne, LC; Lisberger, SG, Spatial and temporal integration of visual motion signals for smooth pursuit eye movements in monkeys., Journal of neurophysiology, vol 102 no. 4 (2009), pp. 2013-2025 [10.1152/jn.00611.2009] [abs].
    • Lisberger, SG, Internal models of eye movement in the floccular complex of the monkey cerebellum., Neuroscience, vol 162 no. 3 (2009), pp. 763-776 [10.1016/j.neuroscience.2009.03.059] [abs].
    • Huang, X; Lisberger, SG, Noise correlations in cortical area MT and their potential impact on trial-by-trial variation in the direction and speed of smooth-pursuit eye movements., Journal of neurophysiology, vol 101 no. 6 (2009), pp. 3012-3030 [10.1152/jn.00010.2009] [abs].
    • Yang, J; Lisberger, SG, Relationship between adapted neural population responses in MT and motion adaptation in speed and direction of smooth-pursuit eye movements., Journal of neurophysiology, vol 101 no. 5 (2009), pp. 2693-2707 [10.1152/jn.00061.2009] [abs].
    • Medina, JF; Lisberger, SG, Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys., Nature Neuroscience, vol 11 no. 10 (2008), pp. 1185-1192 [10.1038/nn.2197] [abs].
    • Heuer, HW; Tokiyama, S; Lisberger, SG, Doing without learning: stimulation of the frontal eye fields and floccular complex does not instruct motor learning in smooth pursuit eye movements., Journal of neurophysiology, vol 100 no. 3 (2008), pp. 1320-1331 [10.1152/jn.90492.2008] [abs].
    • Schoppik, D; Nagel, KI; Lisberger, SG, Cortical mechanisms of smooth eye movements revealed by dynamic covariations of neural and behavioral responses., Neuron, vol 58 no. 2 (2008), pp. 248-260 [10.1016/j.neuron.2008.02.015] [abs].
    • Osborne, LC; Palmer, SE; Lisberger, SG; Bialek, W, Combinatorial coding in neural populations [abs].