Sallie Robey Permar

Image of Sallie Robey Permar

Professor of Pediatrics

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Appointments and Affiliations

  • Professor of Pediatrics
  • Associate Professor in Immunology
  • Professor of Molecular Genetics and Microbiology
  • Affiliate, Duke Global Health Institute
  • Member of the Duke Human Vaccine Institute

Contact Information:

Education:

  • Children's Hospital Boston, 2009
  • Children's Hospital Boston, 2007
  • Ph.D. Johns Hopkins University, 2004
  • M.D. Harvard Medical School, 2004

Awards, Honors, and Distinctions:

  • American Society of Clinical Investigation Inductee. ASCI. 2016
  • Young Investigator Award. Pediatric Infectious Diseases Society. 2015
  • Young Investigator Award. Society for Pediatrics Research. 2014
  • Presidential Early Career Awards for Scientists and Engineers. President of the United States of America. 2012

Courses Taught:

  • IMMUNOL 493: Research Independent Study
  • IMMUNOL 494: Research Independent Study
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

Representative Publications:

    • Sacha, CR; Vandergrift, N; Jeffries, TL; McGuire, E; Fouda, GG; Liebl, B; Marshall, DJ; Gurley, TC; Stiegel, L; Whitesides, JF; Friedman, J; Badiabo, A; Foulger, A; Yates, NL; Tomaras, GD; Kepler, TB; Liao, HX; Haynes, BF; Moody, MA; Permar, SR, Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women., Mucosal immunology, vol 8 no. 2 (2015), pp. 316-326 [10.1038/mi.2014.69] [abs].
    • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Pollara, J; Song, LY; Liebl, BE; Whitaker, K; Shen, X; Vandergrift, NA; Overman, RG; Yates, NL; Moody, MA; Fry, C; Kim, JH; Michael, NL; Robb, M; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Liao, H-X; Haynes, BF; Montefiori, DC; Ferrari, G; Tomaras, GD; Permar, SR, Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses., Journal of Infectious Diseases, vol 211 no. 4 (2015), pp. 508-517 [10.1093/infdis/jiu444] [abs].
    • Chahroudi, A; Cartwright, E; Carnathan, DG; Lee, ST; Lawson, B; Carnathan, PM; Hashempoor, T; Murphy, MK; Meeker, T; Ehnert, S; Souder, C; Else, JG; Cohen, J; Vanderford, TH; Permar, SR; Derdeyn, CA; Villinger, F; Silvestri, G, TARGET CELL AVAILABILITY, RATHER THAN BREAST MILK SPECIFIC FACTORS, DICTATES MOTHER-TO-INFANT TRANSMISSION OF SIV, Journal of Medical Primatology, vol 43 no. 5 (2014), pp. 385-385 [abs].
    • Kaur, A; Barry, P; Bialas, K; Tran, D; Varner, V; Kunz, E; Amos, J; Kirchherr, J; Kattenhorn, L; Wachtman, L; Tanaka, T; Permar, SR, SUCCESSFUL DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF CONGENITAL CYTOMEGALOVIRUS TRANSMISSION, Journal of Medical Primatology, vol 43 no. 5 (2014), pp. 426-426 [abs].
    • Fouda, GG; Permar, SR, Immune-based interventions to prevent postnatal HIV-1 transmission., Trends in Microbiology, vol 22 no. 8 (2014), pp. 425-427 [10.1016/j.tim.2014.04.009] [abs].
    • Madani, N; Princiotto, AM; Schön, A; LaLonde, J; Feng, Y; Freire, E; Park, J; Courter, JR; Jones, DM; Robinson, J; Liao, H-X; Moody, MA; Permar, S; Haynes, B; Smith, AB; Wyatt, R; Sodroski, J, CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies., Journal of virology, vol 88 no. 12 (2014), pp. 6542-6555 [10.1128/jvi.00540-14] [abs].
    • Permar, SR; Staats, HF, Which comes first: the antigen or the adjuvant?, Journal of Clinical Investigation, vol 124 no. 6 (2014), pp. 2364-2365 [10.1172/jci76263] [abs].
    • Chahroudi, A; Cartwright, E; Lee, ST; Mavigner, M; Carnathan, DG; Lawson, B; Carnathan, PM; Hashempoor, T; Murphy, MK; Meeker, T; Ehnert, S; Souder, C; Else, JG; Cohen, J; Collman, RG; Vanderford, TH; Permar, SR; Derdeyn, CA; Villinger, F; Silvestri, G, Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques., PLoS pathogens, vol 10 no. 3 (2014) [10.1371/journal.ppat.1003958] [abs].
    • Meyer, SA; Westreich, DJ; Patel, E; Ehlinger, EP; Kalilani, L; Lovingood, RV; Denny, TN; Swamy, GK; Permar, SR, Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers., Infectious Diseases in Obstetrics and Gynecology (Hindawi), vol 2014 (2014) [10.1155/2014/989721] [abs].
    • Fouda, GG; Jaeger, FH; Amos, JD; Ho, C; Kunz, EL; Anasti, K; Stamper, LW; Liebl, BE; Barbas, KH; Ohashi, T; Moseley, MA; Liao, H-X; Erickson, HP; Alam, SM; Permar, SR, Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk., Proceedings of the National Academy of Sciences of USA, vol 110 no. 45 (2013), pp. 18220-18225 [10.1073/pnas.1307336110] [abs].
    • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Liebl, BE; Liao, H; Haynes, BF; Overman, R; Yates, NL; Tomaras, GD; Permar, SR, HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants, AIDS Research and Human Retroviruses, vol 29 no. 11 (2013), pp. A13-A14 [abs].
    • Kunz, E; Fouda, G; Ho, C; Amos, J; Colvin, L; Montefiori, D; Martelli, A; Allen, A; Aramand, L; Marshall, DJ; Letvin, NL; Staats, H; Pickup, D; Barnett, SC; Moody, MA; Haynes, BF; Liao, H; Permar, SR, Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk, AIDS Research and Human Retroviruses, vol 29 no. 11 (2013), pp. A180-A180 [abs].
    • Sacha, CR; Vandergrift, N; Marshall, DJ; Gurley, TC; Stiegel, L; Whitesides, JF; Friedman, J; Fouda, GG; Liebl, B; McGuire, E; Foulger, A; Kepler, TB; Liao, H; Haynes, BF; Moody, MA; Permar, SR, Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women, AIDS Research and Human Retroviruses, vol 29 no. 11 (2013), pp. A169-A170 [abs].
    • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Colvin, L; Mahlokozera, T; Ho, C; Beck, K; Overman, RG; DeMarco, CT; Hodge, TL; LaBranche, CC; Montefiori, DC; Denny, TN; Liao, H-X; Tomaras, GD; Moody, MA; Permar, SR, Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys., Journal of virology, vol 87 no. 20 (2013), pp. 11121-11134 [10.1128/JVI.01887-13] [abs].
    • Ho, C; Wu, S; Amos, JD; Colvin, L; Smith, SD; Wilks, AB; Demarco, CT; Brinkley, C; Denny, TN; Schmitz, JE; Rodrigo, AG; Permar, SR, Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys., Journal of virology, vol 87 no. 20 (2013), pp. 11292-11299 [10.1128/JVI.01643-13] [abs].
    • Permar, SR; Salazar, MG; Gao, F; Cai, F; Learn, GH; Kalilani, L; Hahn, BH; Shaw, GM; Salazar-Gonzalez, JF, Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis., Retrovirology, vol 10 (2013) [10.1186/1742-4690-10-88] [abs].
    • Fouda, GGA; Amos, JD; Wilks, AB; Pollara, J; Ray, CA; Chand, A; Kunz, EL; Liebl, BE; Whitaker, K; Carville, A; Smith, S; Colvin, L; Pickup, DJ; Staats, HF; Overman, G; Eutsey-Lloyd, K; Parks, R; Chen, H; Labranche, C; Barnett, S; Tomaras, GD; Ferrari, G; Montefiori, DC; Liao, H-X; Letvin, NL; Haynes, BF; Permar, SR, Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk., Journal of virology, vol 87 no. 12 (2013), pp. 6986-6999 [10.1128/JVI.00528-13] [abs].
    • Fouda, GG; Mahlokozera, T; Salazar-Gonzalez, JF; Salazar, MG; Learn, G; Kumar, SB; Dennison, SM; Russell, E; Rizzolo, K; Jaeger, F; Cai, F; Vandergrift, NA; Gao, F; Hahn, B; Shaw, GM; Ochsenbauer, C; Swanstrom, R; Meshnick, S; Mwapasa, V; Kalilani, L; Fiscus, S; Montefiori, D; Haynes, B; Kwiek, J; Alam, SM; Permar, SR, Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants., Retrovirology, vol 10 (2013) [10.1186/1742-4690-10-3] [abs].
    • Handley, SA; Thackray, LB; Zhao, G; Presti, R; Miller, AD; Droit, L; Abbink, P; Maxfield, LF; Kambal, A; Duan, E; Stanley, K; Kramer, J; Macri, SC; Permar, SR; Schmitz, JE; Mansfield, K; Brenchley, JM; Veazey, RS; Stappenbeck, TS; Wang, D; Barouch, DH; Virgin, HW, Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome., Cell, vol 151 no. 2 (2012), pp. 253-266 [10.1016/j.cell.2012.09.024] [abs].
    • Russell, ES; Ojeda, S; Fouda, G; Meshnick, SR; Montefiori, D; Permar, SR; Swanstrom, R, HIV-1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly-neutralizing antibodies directed against quaternary and CD4-binding site epitopes., AIDS Research and Human Retroviruses (2012) [10.1089/AID.2012.0197] [abs].
    • Schmitz, JE; Ma, Z-M; Hagan, EA; Wilks, AB; Furr, KL; Linde, CH; Zahn, RC; Brenchley, JM; Miller, CJ; Permar, SR, Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys., Journal of virology, vol 86 no. 20 (2012), pp. 11380-11385 [10.1128/JVI.01556-12] [abs].
    • Fouda, G; Amos, J; Wilks, AB; Chand, A; Montefiori, D; Haynes, B; Letvin, N; Pickup, D; Liao, H; Permar, SR, Vaccine-elicited systemic and mucosal humoral responses of lactating rhesus monkeys vaccinated with the transmitted/founder HIV Envelope 1086C, Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-S2-O20] [abs].
    • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Overman, GR; Beck, K; Moody, MA; Tomaras, GD; Permar, SR, Strong SIV gp120-specific IgG/IgA responses in milk of African green monkeys may contribute to the rarity of postnatal transmission in this species, Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-S2-P198] [abs].
    • Parrish, NF; Wilen, CB; Banks, LB; Iyer, SS; Pfaff, JM; Salazar-Gonzalez, JF; Salazar, MG; Decker, JM; Parrish, EH; Berg, A; Hopper, J; Hora, B; Kumar, A; Mahlokozera, T; Yuan, S; Coleman, C; Vermeulen, M; Ding, H; Ochsenbauer, C; Tilton, JC; Permar, SR; Kappes, JC; Betts, MR; Busch, MP; Gao, F; Montefiori, D; Haynes, BF; Shaw, GM; Hahn, BH; Doms, RW, Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7., PLoS pathogens, vol 8 no. 5 (2012) [10.1371/journal.ppat.1002686] [abs].
    • Friedman, J; Alam, SM; Shen, X; Xia, S-M; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, H-X; Moody, MA; Permar, SR, Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum., PloS one, vol 7 no. 5 (2012) [10.1371/journal.pone.0037648] [abs].
    • Ehlinger, EP; Webster, EM; Kang, HH; Cangialose, A; Simmons, AC; Barbas, KH; Burchett, SK; Gregory, ML; Puopolo, KM; Permar, SR, Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants., Journal of Infectious Diseases, vol 204 no. 11 (2011), pp. 1672-1682 [10.1093/infdis/jir632] [abs].
    • Wilks, AB; Perry, JR; Ehlinger, EP; Zahn, RC; White, R; Gauduin, M-C; Carville, A; Seaman, MS; Schmitz, JE; Permar, SR, High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus-infected african green monkeys., Journal of virology, vol 85 no. 18 (2011), pp. 9517-9526 [10.1128/JVI.00796-11] [abs].
    • Fouda, GG; Yates, NL; Pollara, J; Shen, X; Overman, GR; Mahlokozera, T; Wilks, AB; Kang, HH; Salazar-Gonzalez, JF; Salazar, MG; Kalilani, L; Meshnick, SR; Hahn, BH; Shaw, GM; Lovingood, RV; Denny, TN; Haynes, B; Letvin, NL; Ferrari, G; Montefiori, DC; Tomaras, GD; Permar, SR; Center for HIV/AIDS Vaccine Immunology, , HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies., Journal of virology, vol 85 no. 18 (2011), pp. 9555-9567 [10.1128/JVI.05174-11] [abs].
    • Sun, Y; Asmal, M; Lane, S; Permar, SR; Schmidt, SD; Mascola, JR; Letvin, NL, Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys., Journal of virology, vol 85 no. 14 (2011), pp. 6906-6912 [10.1128/JVI.00326-11] [abs].
    • Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Fouda, GG; Kang, HH; Mahlokozera, T; Wilks, AB; Lovingood, RV; Stacey, A; Kalilani, L; Meshnick, SR; Borrow, P; Montefiori, DC; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR; Center for HIV/AIDS Vaccine Immunology A0167854, , Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing., Journal of virology, vol 85 no. 6 (2011), pp. 2751-2763 [10.1128/JVI.02316-10] [abs].
    • Mahlokozera, T; Kang, HH; Goonetilleke, N; Stacey, AR; Lovingood, RV; Denny, TN; Kalilani, L; Bunn, JEG; Meshnick, SR; Borrow, P; Letvin, NL; Permar, SR; Center for HIV/AIDS Vaccine Immunology, , The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk., PloS one, vol 6 no. 8 (2011) [10.1371/journal.pone.0023735] [abs].
    • Wilks, AB; Christian, EC; Seaman, MS; Sircar, P; Carville, A; Gomez, CE; Esteban, M; Pantaleo, G; Barouch, DH; Letvin, NL; Permar, SR, Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys., Journal of immunology (Baltimore, Md. : 1950), vol 185 no. 11 (2010), pp. 7097-7106 [10.4049/jimmunol.1002751] [abs].
    • Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Kang, HH; Mahlokozera, T; Kalilani, L; Meshnick, SR; Lovingood, RV; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR, Local production of HIV variants in breast milk of chronically HIV-infected, lactating women, AIDS Research and Human Retroviruses, vol 26 no. 10 (2010), pp. A148-A148 [abs].
    • Permar, SR; Wilks, AB; Ehlinger, EP; Kang, HH; Mahlokozera, T; Coffey, RT; Carville, A; Letvin, NL; Seaman, MS, Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys., Journal of virology, vol 84 no. 16 (2010), pp. 8209-8218 [10.1128/JVI.00656-10] [abs].
    • Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL, Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys., Retrovirology, vol 7 (2010) [10.1186/1742-4690-7-7] [abs].
    • Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL, Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys, Retrovirology, vol 7 (2010) [10.1186/1742-4690-7-7] [abs].
    • Permar, SR; Kang, HH; Carville, A; Wilks, AB; Mansfield, KG; Rao, SS; Letvin, NL, Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection., Journal of Infectious Diseases, vol 201 no. 2 (2010), pp. 302-310 [10.1086/649229] [abs].
    • Permar, SR; Kang, HH; Carville, A; Mansfield, KG; Gelman, RS; Rao, SS; Whitney, JB; Letvin, NL, Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys., Journal of immunology (Baltimore, Md. : 1950), vol 181 no. 5 (2008), pp. 3643-3650 [abs].
    • Permar, SR; Rao, SS; Sun, Y; Bao, S; Buzby, AP; Kang, HH; Letvin, NL, Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys., Journal of Infectious Diseases, vol 196 no. 12 (2007), pp. 1784-1793 [10.1086/522967] [abs].
    • Sun, Y; Permar, SR; Buzby, AP; Letvin, NL, Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection., Journal of virology, vol 81 no. 15 (2007), pp. 8009-8015 [10.1128/JVI.00482-07] [abs].
    • Permar, SR; Griffin, DE; Letvin, NL, Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals., Clinical and vaccine immunology : CVI, vol 13 no. 4 (2006), pp. 437-443 [10.1128/CVI.13.4.437-443.2006] [abs].
    • Permar, SR; Griffin, DE; Letvin, NL, Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals, Clinical and vaccine immunology : CVI, vol 13 no. 4 (2006), pp. 437-443 [10.1128/CVI.13.4-437-443.2006] [abs].
    • Permar, SR; Klumpp, SA; Mansfield, KG; Carville, AAL; Gorgone, DA; Lifton, MA; Schmitz, JE; Reimann, KA; Polack, FP; Griffin, DE; Letvin, NL, Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys., Journal of Infectious Diseases, vol 190 no. 5 (2004), pp. 998-1005 [10.1086/422846] [abs].
    • Permar, SR; Moss, WJ; Ryon, JJ; Douek, DC; Monze, M; Griffin, DE, Increased thymic output during acute measles virus infection., Journal of virology, vol 77 no. 14 (2003), pp. 7872-7879 [abs].
    • Permar, SR; Klumpp, SA; Mansfield, KG; Kim, W-K; Gorgone, DA; Lifton, MA; Williams, KC; Schmitz, JE; Reimann, KA; Axthelm, MK; Polack, FP; Griffin, DE; Letvin, NL, Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys., Journal of virology, vol 77 no. 7 (2003), pp. 4396-4400 [abs].
    • Permar, SR; Moss, WJ; Ryon, JJ; Monze, M; Cutts, F; Quinn, TC; Griffin, DE, Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction., Journal of Infectious Diseases, vol 183 no. 4 (2001), pp. 532-538 [10.1086/318533] [abs].