Mary E Klotman
R.J. Reynolds Professor of Medicine
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.
Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.
Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)
Appointments and Affiliations
- R.J. Reynolds Professor of Medicine
- Professor of Medicine
- Professor of Pathology
- Professor in Molecular Genetics and Microbiology
- Member of the Duke Human Vaccine Institute
- Chair, Department of Medicine
- Office Location: Duke Hospital North Room 1102, Box 3703, Durham, NC 27710
- Office Phone: (919) 668-1755
- Email Address: firstname.lastname@example.org
- Web Page:
- Duke University, 1985
- Duke University, 1983
- M.D. Duke University, 1980
Awards, Honors, and Distinctions:
- Membership. National Academy of Medicine. 2014
- PATHOL 793: Research Independent Study
- Michelini, Z; Negri, D; Biava, M; Baroncelli, S; Spada, M; Leone, P; Bona, R; Blasi, M; Nègre, D; Klotman, ME; Cara, A, Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice., Viral Immunology, vol 27 no. 10 (2014), pp. 512-520 [10.1089/vim.2014.0062] [abs].
- Blasi, M; Balakumaran, B; Chen, P; Negri, DRM; Cara, A; Chen, BK; Klotman, ME, Renal epithelial cells produce and spread HIV-1 via T-cell contact., AIDS, vol 28 no. 16 (2014), pp. 2345-2353 [10.1097/qad.0000000000000398] [abs].
- Micsenyi, AM; Zony, C; Alvarez, RA; Durham, ND; Chen, BK; Klotman, ME, Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells., Journal of Infectious Diseases, vol 208 no. 11 (2013), pp. 1756-1767 [10.1093/infdis/jit362] [abs].
- Hutter, R; Huang, L; Speidl, WS; Giannarelli, C; Trubin, P; Bauriedel, G; Klotman, ME; Fuster, V; Badimon, JJ; Klotman, PE, Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma., Circulation, vol 128 no. 22 (2013), pp. 2351-2363 [10.1161/CIRCULATIONAHA.113.004634] [abs].
- Blasi, M; Negri, D; Santra, S; Parks, R; Shen, X; Tomaras, G; Permar, S; Montefiori, D; LaBranche, C; Ferrari, G; Alam, M; Liao, H; Moody, AM; Haynes, BF; Klotman, ME; Cara, A, A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys, AIDS Research and Human Retroviruses, vol 29 no. 11 (2013), pp. A161-A161 [abs].
- Todd, RF; Salata, RA; Klotman, ME; Weisfeldt, ML; Katz, JT; Xian, SX; Hearn, DP; Lipner, RS, Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007., Academic Medicine, vol 88 no. 11 (2013), pp. 1747-1753 [10.1097/ACM.0b013e3182a7f627] [abs].
- Blasi, M; Rossi, A; Michelini, Z; Leone, P; Perretta, G; Cimarelli, A; Klotman, ME; Negri, D; Cara, A, Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines, Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-S2-P293] [abs].
- Negri, DRM; Rossi, A; Blasi, M; Michelini, Z; Leone, P; Chiantore, MV; Baroncelli, S; Perretta, G; Cimarelli, A; Klotman, ME; Cara, A, Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines., Retrovirology, vol 9 (2012) [10.1186/1742-4690-9-69] [abs].
- Papeta, N; Kiryluk, K; Patel, A; Sterken, R; Kacak, N; Snyder, HJ; Imus, PH; Mhatre, AN; Lawani, AK; Julian, BA; Wyatt, RJ; Novak, J; Wyatt, CM; Ross, MJ; Winston, JA; Klotman, ME; Cohen, DJ; Appel, GB; D'Agati, VD; Klotman, PE; Gharavi, AG, APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy., Journal of the American Society of Nephrology : JASN, vol 22 no. 11 (2011), pp. 1991-1996 [10.1681/ASN.2011040434] [abs].
- Chen, P; Chen, BK; Mosoian, A; Hays, T; Ross, MJ; Klotman, PE; Klotman, ME, Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells., Journal of the American Society of Nephrology : JASN, vol 22 no. 3 (2011), pp. 496-507 [10.1681/ASN.2010040379] [abs].
- Jao, J; Palmer, D; Leus, I; Tih, P; Baweja, M; Klotman, M; Sperling, R; Wyatt, C, Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon, Nephrology Dialysis Transplantation, vol 26 no. 9 (2011), pp. 3051-3053 [10.1093/ndt/gfr310] [abs].
- Ding, J; Rapista, A; Teleshova, N; Lu, W; Klotman, ME; Chang, TL, Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides., Journal of Innate Immunity, vol 3 no. 2 (2011), pp. 208-212 [10.1159/000322355] [abs].