Louis Edwin DeFrate

Louis Edwin DeFrate

Frank H. Bassett III, M. D. Associate Professor

Appointments and Affiliations

  • Frank H. Bassett III, M. D. Associate Professor
  • Associate Professor in Orthopaedic Surgery
  • Associate Professor in the Department of Mechanical Engineering and Material Science
  • Associate Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Martin, JT; Oldweiler, AB; Spritzer, CE; Soher, BJ; Erickson, MM; Goode, AP; DeFrate, LE, A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape., Journal of Biomechanics, vol 71 (2018), pp. 291-295 [10.1016/j.jbiomech.2018.01.045] [abs].
  • Owusu-Akyaw, KA; Heckelman, LN; Cutcliffe, HC; Sutter, EG; Englander, ZA; Spritzer, CE; Garrett, WE; DeFrate, LE, A comparison of patellofemoral cartilage morphology and deformation in anterior cruciate ligament deficient versus uninjured knees., Journal of Biomechanics, vol 67 (2018), pp. 78-83 [10.1016/j.jbiomech.2017.11.019] [abs].
  • Liu, B; Lad, NK; Collins, AT; Ganapathy, PK; Utturkar, GM; McNulty, AL; Spritzer, CE; Moorman, CT; Sutter, EG; Garrett, WE; DeFrate, LE, In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking., American Journal of Sports Medicine, vol 45 no. 12 (2017), pp. 2817-2823 [10.1177/0363546517712506] [abs].
  • DeFrate, LE, Effects of ACL graft placement on in vivo knee function and cartilage thickness distributions., Journal of Orthopaedic Research, vol 35 no. 6 (2017), pp. 1160-1170 [10.1002/jor.23541] [abs].
  • Liu, B; Goode, AP; Carter, TE; Utturkar, GM; Huebner, JL; Taylor, DC; Moorman, CT; Garrett, WE; Kraus, VB; Guilak, F; DeFrate, LE; McNulty, AL, Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients., Connective Tissue Research (Informa), vol 58 no. 3-4 (2017), pp. 305-316 [10.1080/03008207.2016.1256391] [abs].