Kim Marie Huffman

Image of Kim Marie Huffman

Associate Professor of Medicine

Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis)

Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis

Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as individuals engaging in regular exercise

Addressing the role of physical activity in modulating inflammation, metabolism, and functional health in aging populations

Appointments and Affiliations

  • Associate Professor of Medicine
  • Member of Duke Molecular Physiology Institute
  • Affiliate of the Regeneration Next Initiative

Contact Information:

  • Office Location: 300 N Duke St, Carmichael, 51-202, Durham, NC 27701
  • Office Phone: (919) 668-1644
  • Email Address: huffm007@mc.duke.edu

Education:

  • Duke University, 2005
  • Duke University, 2002
  • M.D. Medical University of South Carolina School of Medicine, 2000
  • Ph.D. Medical University of South Carolina School of Medicine, 1998

Representative Publications:

    • Huffman, KM; Pieper, CF; Kraus, VB; Kraus, WE; Fillenbaum, GG; Cohen, HJ, Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults., Journals of Gerontology: Series A, vol 66 no. 12 (2011), pp. 1369-1375 [10.1093/gerona/glr121] [abs].
    • Slentz, CA; Bateman, LA; Willis, LH; Shields, AT; Tanner, CJ; Piner, LW; Hawk, VH; Muehlbauer, MJ; Samsa, GP; Nelson, RC; Huffman, KM; Bales, CW; Houmard, JA; Kraus, WE, Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT., American journal of physiology. Endocrinology and metabolism, vol 301 no. 5 (2011), pp. E1033-E1039 [10.1152/ajpendo.00291.2011] [abs].
    • Huffman, KM; Slentz, CA; Kraus, WE, Control arms in exercise training studies: transitioning from an era of intervention efficacy to one of comparative clinical effectiveness research., Journal of applied physiology (Bethesda, Md. : 1985), vol 111 no. 3 (2011), pp. 946-948 [10.1152/japplphysiol.00323.2011] [abs].
    • Lum, H; Sloane, R; Huffman, KM; Kraus, VB; Thompson, DK; Kraus, WE; Bain, JR; Stevens, R; Pieper, CF; Taylor, GA; Newgard, CB; Cohen, HJ; Morey, MC, Plasma acylcarnitines are associated with physical performance in elderly men., Journals of Gerontology: Series A, vol 66 no. 5 (2011), pp. 548-553 [10.1093/gerona/glr006] [abs].
    • Denoble, AE; Huffman, KM; Stabler, TV; Kelly, SJ; Hershfield, MS; McDaniel, GE; Coleman, RE; Kraus, VB, Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation., Proceedings of the National Academy of Sciences of USA, vol 108 no. 5 (2011), pp. 2088-2093 [10.1073/pnas.1012743108] [abs].
    • Redman, LM; Huffman, KM; Landerman, LR; Pieper, CF; Bain, JR; Muehlbauer, MJ; Stevens, RD; Wenner, BR; Kraus, VB; Newgard, CB; Kraus, WE; Ravussin, E, Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women., Journal of Clinical Endocrinology and Metabolism, vol 96 no. 2 (2011), pp. E312-E321 [10.1210/jc.2010-1971] [abs].
    • Huffman, KM; Slentz, CA; Bateman, LA; Thompson, D; Muehlbauer, MJ; Bain, JR; Stevens, RD; Wenner, BR; Kraus, VB; Newgard, CB; Kraus, WE, Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity., Diabetes Care, vol 34 no. 1 (2011), pp. 174-176 [10.2337/dc10-0709] [abs].
    • Hittel, DS; Axelson, M; Sarna, N; Shearer, J; Huffman, KM; Kraus, WE, Myostatin decreases with aerobic exercise and associates with insulin resistance., Medicine and Science in Sports and Exercise, vol 42 no. 11 (2010), pp. 2023-2029 [10.1249/MSS.0b013e3181e0b9a8] [abs].
    • Hoenig, H; Huffman, K; Iezzoni, L; Levy, CE; Sonenblum, S; Sprigle, S, Motorized scooters: boon or bane?, American Journal of Cardiology, vol 106 no. 4 (2010) [10.1016/j.amjcard.2010.05.018] [abs].
    • Huffman, KM; Sloane, R; Peterson, MJ; Bosworth, HB; Ekelund, C; Pearson, M; Howard, T; Pieper, CF; Morey, MC, The impact of self-reported arthritis and diabetes on response to a home-based physical activity counselling intervention., Scandinavian Journal of Rheumatology (Informa), vol 39 no. 3 (2010), pp. 233-239 [10.3109/03009740903348973] [abs].
    • Huffman, KM; Hall, KS; Sloane, R; Peterson, MJ; Bosworth, HB; Ekelund, C; Pearson, M; Howard, T; Pieper, CF; Morey, MC, Is diabetes associated with poorer self-efficacy and motivation for physical activity in older adults with arthritis?, Scandinavian Journal of Rheumatology (Informa), vol 39 no. 5 (2010), pp. 380-386 [10.3109/03009741003605630] [abs].
    • Slentz, CA; Tanner, CJ; Bateman, LA; Durheim, MT; Huffman, KM; Houmard, JA; Kraus, WE, Effects of exercise training intensity on pancreatic beta-cell function., Diabetes Care, vol 32 no. 10 (2009), pp. 1807-1811 [10.2337/dc09-0032] [abs].
    • Huffman, KM; Shah, SH; Stevens, RD; Bain, JR; Muehlbauer, M; Slentz, CA; Tanner, CJ; Kuchibhatla, M; Houmard, JA; Newgard, CB; Kraus, WE, Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women., Diabetes Care, vol 32 no. 9 (2009), pp. 1678-1683 [10.2337/dc08-2075] [abs].
    • Smith, IJ; Huffman, KM; Durheim, MT; Duscha, BD; Kraus, WE, Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise., Physiological genomics, vol 36 no. 3 (2009), pp. 149-157 [10.1152/physiolgenomics.90216.2008] [abs].
    • Huffman, KM; Slentz, CA; Johnson, JL; Samsa, GP; Duscha, BD; Tanner, CJ; Annex, BH; Houmard, JA; Kraus, WE, Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults., Metabolism, vol 57 no. 7 (2008), pp. 888-895 [10.1016/j.metabol.2008.01.034] [abs].
    • Huffman, KM; Slentz, CA; Bales, CW; Houmard, JA; Kraus, WE, Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention., Metabolism, vol 57 no. 4 (2008), pp. 577-583 [10.1016/j.metabol.2007.11.023] [abs].
    • Huffman, KM; Orenduff, MC; Samsa, GP; Houmard, JA; Kraus, WE; Bales, CW, Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men., American Heart Journal, vol 154 no. 5 (2007), pp. 962-968 [10.1016/j.ahj.2007.07.009] [abs].
    • Huffman, KM; Bowers, JR; Dailiana, Z; Huebner, JL; Urbaniak, JR; Kraus, VB, Synovial fluid metabolites in osteonecrosis., Rheumatology, vol 46 no. 3 (2007), pp. 523-528 [10.1093/rheumatology/kel302] [abs].
    • Huffman, KM; Samsa, GP; Slentz, CA; Duscha, BD; Johnson, JL; Bales, CW; Tanner, CJ; Houmard, JA; Kraus, WE, Response of high-sensitivity C-reactive protein to exercise training in an at-risk population., American Heart Journal, vol 152 no. 4 (2006), pp. 793-800 [10.1016/j.ahj.2006.04.019] [abs].
    • Huffman, KM; Arrigo, SJ; Schmidt, MG, HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system., Journal of Biomedical Science, vol 6 no. 3 (1999), pp. 194-205 [abs].
    • Huffman, KM; Arrigo, SJ, Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences., Virology, vol 234 no. 2 (1997), pp. 253-260 [10.1006/viro.1997.8655] [abs].
    • Arrigo, SJ; Huffman, K, Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers., Journal of virology, vol 69 no. 10 (1995), pp. 5988-5994 [abs].
    • Arrigo, SJ; Haines, JK; Huffman, KM, Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells., DNA and Cell Biology, vol 14 no. 1 (1995), pp. 15-23 [10.1089/dna.1995.14.15] [abs].
    • English, RS; Lorbach, SC; Huffman, KM; Shively, JM, Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid., Plasmid, vol 33 no. 1 (1995), pp. 1-6 [10.1006/plas.1995.1001] [abs].
    • Ella, KM; Meier, GP; Bradshaw, CD; Huffman, KM; Spivey, EC; Meier, KE, A fluorescent assay for agonist-activated phospholipase D in mammalian cell extracts., Analytical Biochemistry, vol 218 no. 1 (1994), pp. 136-142 [10.1006/abio.1994.1152] [abs].