Joseph Geradts

Image of Joseph Geradts

Adjunct Professor in the Department of Pathology

Dr. Geradts' primary research focus is on the molecular pathology of breast cancer. His laboratory uses genomic profiling strategies to identify novel candidate breast cancer genes. Dr. Geradts is also interested in biomarker development. He directs the Tissue Core of Duke's Breast Cancer SPORE and collaborates on numerous breast cancer related research projects with other investigators at Duke and elsewhere.

Appointments and Affiliations

  • Adjunct Professor in the Department of Pathology

Contact Information:

  • Office Location: Rm 3108 Meyer Ward, Department of Pathology, Durham, NC 27710
  • Office Phone: (919) 684-2452
  • Email Address: joseph.geradts@duke.edu

Education:

  • State University of New York at Buffalo, 2005
  • University of North Carolina at Chapel Hill, 1993
  • National Institutes of Health, 1991
  • Stanford University, 1990
  • University of California, San Francisco, School of Medicine, 1989
  • M.D. University of Chicago, 1987
  • M.A. University of California at Berkeley, 1984

Representative Publications:

    • Barry, WT; Kernagis, DN; Dressman, HK; Griffis, RJ; Hunter, JD; Olson, JA; Marks, JR; Ginsburg, GS; Marcom, PK; Nevins, JR; Geradts, J; Datto, MB, Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome., Journal of Clinical Oncology, vol 28 no. 13 (2010), pp. 2198-2206 [10.1200/JCO.2009.26.7245] [abs].
    • Sood, AK; Wang, J; Mhawech-Fauceglia, P; Jana, B; Liang, P; Geradts, J, Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 18 no. 6 (2009), pp. 1899-1903 [10.1158/1055-9965.EPI-09-0055] [abs].
    • Brown, JQ; Wilke, LG; Geradts, J; Kennedy, SA; Palmer, GM; Ramanujam, N, Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo., Cancer Research, vol 69 no. 7 (2009), pp. 2919-2926 [10.1158/0008-5472.CAN-08-3370] [abs].
    • Ramanujam, N; Brown, J; Bydlon, TM; Kennedy, SA; Richards, LM; Junker, MK; Gallagher, J; Barry, WT; Wilke, LG; Geradts, J, Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment., Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol 2009 (2009), pp. 6554-6556 [10.1109/IEMBS.2009.5334501] [abs].
    • Millikan, RC; Newman, B; Tse, C-K; Moorman, PG; Conway, K; Dressler, LG; Smith, LV; Labbok, MH; Geradts, J; Bensen, JT; Jackson, S; Nyante, S; Livasy, C; Carey, L; Earp, HS; Perou, CM, Epidemiology of basal-like breast cancer., Breast Cancer Research and Treatment, vol 109 no. 1 (2008), pp. 123-139 [10.1007/s10549-007-9632-6] [abs].
    • Sood, AK; Saxena, R; Groth, J; Desouki, MM; Cheewakriangkrai, C; Rodabaugh, KJ; Kasyapa, CS; Geradts, J, Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression., Human Pathology, vol 38 no. 11 (2007), pp. 1628-1638 [10.1016/j.humpath.2007.03.010] [abs].
    • Huang, H; Sossey-Alaoui, K; Beachy, SH; Geradts, J, The tetraspanin superfamily member NET-6 is a new tumor suppressor gene., Journal of Cancer Research and Clinical Oncology, vol 133 no. 10 (2007), pp. 761-769 [10.1007/s00432-007-0221-1] [abs].
    • Carey, LA; Perou, CM; Livasy, CA; Dressler, LG; Cowan, D; Conway, K; Karaca, G; Troester, MA; Tse, CK; Edmiston, S; Deming, SL; Geradts, J; Cheang, MCU; Nielsen, TO; Moorman, PG; Earp, HS; Millikan, RC, Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study., JAMA : the journal of the American Medical Association, vol 295 no. 21 (2006), pp. 2492-2502 [10.1001/jama.295.21.2492] [abs].
    • Varma, G; Varma, R; Huang, H; Pryshchepava, A; Groth, J; Fleming, D; Nowak, NJ; McQuaid, D; Conroy, J; Mahoney, M; Moysich, K; Falkner, KL; Geradts, J, Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York., British Journal of Cancer, vol 93 no. 6 (2005), pp. 699-708 [10.1038/sj.bjc.6602784] [abs].
    • Huang, H; Groth, J; Sossey-Alaoui, K; Hawthorn, L; Beall, S; Geradts, J, Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors., Clinical cancer research : an official journal of the American Association for Cancer Research, vol 11 no. 12 (2005), pp. 4357-4364 [10.1158/1078-0432.CCR-04-2107] [abs].
    • Geradts, J, Abrogation of the RB-p16 tumor suppressor pathway in human lung cancer., Methods in Molecular Medicine, vol 74 (2003), pp. 89-99 [abs].
    • Wilson, KS; Roberts, H; Leek, R; Harris, AL; Geradts, J, Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues., The American journal of pathology, vol 161 no. 4 (2002), pp. 1171-1185 [10.1016/S0002-9440(10)64394-5] [abs].