Hashim Al-Hashimi

Hashim Al-Hashimi

James B. Duke Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Professor of Biochemistry
  • Professor of Biochemistry
  • Professor of Chemistry

Contact Information:

  • Email Address: hashim.al.hashimi@duke.edu


  • Ph.D. Yale University, 2000

Courses Taught:

  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Macromolecular Structure Determination by NMR Spectroscopy and X-ray Crystallography
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

Representative Publications:

    • Vaidyanathan, PP; AlSadhan, I; Merriman, DK; Al-Hashimi, HM; Herschlag, D, Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions., RNA (New York, N.Y.), vol 23 no. 5 (2017), pp. 611-618 [10.1261/rna.060053.116] [abs].
    • Szymanski, ES; Kimsey, IJ; Al-Hashimi, HM, Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs., Journal of the American Chemical Society, vol 139 no. 12 (2017), pp. 4326-4329 [10.1021/jacs.7b01156] [abs].
    • Ganser, LR; Al-Hashimi, HM, HIV-1 leader RNA dimeric interface revealed by NMR., Proceedings of the National Academy of Sciences of USA, vol 113 no. 47 (2016), pp. 13263-13265 [10.1073/pnas.1615789113] [abs].
    • Shakya, A; Al-Hashimi, HM; Banaszak Holl, MM, Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies, ACS Macro Letters, vol 5 no. 10 (2016), pp. 1104-1108 [10.1021/acsmacrolett.6b00668] [abs].
    • Gracia, B; Xue, Y; Bisaria, N; Herschlag, D; Al-Hashimi, HM; Russell, R, RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly., Journal of Molecular Biology, vol 428 no. 20 (2016), pp. 3972-3985 [10.1016/j.jmb.2016.07.013] [abs].