Hashim Al-Hashimi

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James B. Duke Professor of Biochemistry

Appointments and Affiliations

  • James B. Duke Professor of Biochemistry
  • Professor of Biochemistry
  • Professor of Chemistry

Contact Information

  • Email Address: hashim.al.hashimi@duke.edu


  • Ph.D. Yale University, 2000

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 695: Understanding NMR Spectroscopy
  • PHARM 493: Research Independent Study
  • PHARM 494: Research Independent Study

In the News

Representative Publications

  • Gracia, B; Al-Hashimi, HM; Bisaria, N; Das, R; Herschlag, D; Russell, R, Hidden Structural Modules in a Cooperative RNA Folding Transition., Cell Reports, vol 22 no. 12 (2018), pp. 3240-3250 [10.1016/j.celrep.2018.02.101] [abs].
  • Kimsey, IJ; Szymanski, ES; Zahurancik, WJ; Shakya, A; Xue, Y; Chu, C-C; Sathyamoorthy, B; Suo, Z; Al-Hashimi, HM, Dynamic basis for dG•dT misincorporation via tautomerization and ionization., Nature, vol 554 no. 7691 (2018), pp. 195-201 [10.1038/nature25487] [abs].
  • Salmon, L; Stull, F; Sayle, S; Cato, C; Akgül, Ş; Foit, L; Ahlstrom, LS; Eisenmesser, EZ; Al-Hashimi, HM; Bardwell, JCA; Horowitz, S, The Mechanism of HdeA Unfolding and Chaperone Activation., Journal of Molecular Biology, vol 430 no. 1 (2018), pp. 33-40 [10.1016/j.jmb.2017.11.002] [abs].
  • Clay, MC; Ganser, LR; Merriman, DK; Al-Hashimi, HM, Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics., Nucleic Acids Research, vol 45 no. 14 (2017) [10.1093/nar/gkx525] [abs].
  • Stelling, AL; Xu, Y; Zhou, H; Choi, SH; Clay, MC; Merriman, DK; Al-Hashimi, HM, Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA., FEBS Letters, vol 591 no. 12 (2017), pp. 1770-1784 [10.1002/1873-3468.12681] [abs].