Charles Gersbach

Image of Charles Gersbach

Rooney Family Associate Professor of Biomedical Engineering

Appointments and Affiliations

  • Rooney Family Associate Professor of Biomedical Engineering
  • Associate Professor of Biomedical Engineering
  • Associate Professor of Orthopaedic Surgery
  • Associate of the Duke Initiative for Science & Society
  • Member of the Duke Cancer Institute
  • Affiliate of the Regeneration Next Initiative

Contact Information:

Education:

  • Ph.D. Georgia Institute of Technology, 2006
  • B.S. Georgia Institute of Technology, 2001

Courses Taught:

  • BME 260L: Modeling Cellular and Molecular Systems
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 562: Biology by Design (GE, MC)
  • BME 712S: Biological Engineering Seminar Series (CBIMMS and CBTE)
  • BME 791: Graduate Independent Study
  • EGR 391: Projects in Engineering
  • EGR 393: Research Projects in Engineering
  • GENOME 293: Research Independent Study Genome Sciences
  • ME 718S: Biological Engineering Seminar Series (CBIMMS and CBTE)

Representative Publications:

    • Black, JB; Adler, AF; Wang, H-G; D'Ippolito, AM; Hutchinson, HA; Reddy, TE; Pitt, GS; Leong, KW; Gersbach, CA, Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells., Cell Stem Cell, vol 19 no. 3 (2016), pp. 406-414 [10.1016/j.stem.2016.07.001] [abs].
    • Maeder, ML; Gersbach, CA, Genome-editing Technologies for Gene and Cell Therapy., Molecular Therapy, vol 24 no. 3 (2016), pp. 430-446 [10.1038/mt.2016.10] [abs].
    • Thakore, PI; Black, JB; Hilton, IB; Gersbach, CA, Editing the epigenome: technologies for programmable transcription and epigenetic modulation., Nature Methods, vol 13 no. 2 (2016), pp. 127-137 [10.1038/nmeth.3733] [abs].
    • Nelson, CE; Hakim, CH; Ousterout, DG; Thakore, PI; Moreb, EA; Castellanos Rivera, RM; Madhavan, S; Pan, X; Ran, FA; Yan, WX; Asokan, A; Zhang, F; Duan, D; Gersbach, CA, In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy., Science, vol 351 no. 6271 (2016), pp. 403-407 [10.1126/science.aad5143] [abs].
    • Thakore, PI; D'Ippolito, AM; Song, L; Safi, A; Shivakumar, NK; Kabadi, AM; Reddy, TE; Crawford, GE; Gersbach, CA, Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements., Nature Methods, vol 12 no. 12 (2015), pp. 1143-1149 [10.1038/nmeth.3630] [abs].
    • Hilton, IB; D'Ippolito, AM; Vockley, CM; Thakore, PI; Crawford, GE; Reddy, TE; Gersbach, CA, Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers., Nature Biotechnology, vol 33 no. 5 (2015), pp. 510-517 [10.1038/nbt.3199] [abs].
    • Polstein, LR; Gersbach, CA, A light-inducible CRISPR-Cas9 system for control of endogenous gene activation., Nature Chemical Biology, vol 11 no. 3 (2015), pp. 198-200 [10.1038/nchembio.1753] [abs].
    • Ousterout, DG; Kabadi, AM; Thakore, PI; Majoros, WH; Reddy, TE; Gersbach, CA, Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy., Nature Communications, vol 6 (2015) [10.1038/ncomms7244] [abs].
    • Perez-Pinera, P; Kocak, DD; Vockley, CM; Adler, AF; Kabadi, AM; Polstein, LR; Thakore, PI; Glass, KA; Ousterout, DG; Leong, KW; Guilak, F; Crawford, GE; Reddy, TE; Gersbach, CA, RNA-guided gene activation by CRISPR-Cas9-based transcription factors., Nature Methods, vol 10 no. 10 (2013), pp. 973-976 [10.1038/nmeth.2600] [abs].